Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X)
1_MTEAG 6_ KLPLP 11_ LPPRL 16_ DWFVH 21_ TQMGQ 26_ LAQDG 31_ VPEWF 36_ HGAIS 41_ REDAE 46_ NLLES 51_ QPLGS 56_ FLIRV 61_ SHSHV 66_ GYTLS 71_ YKAQS 76_ SCCHF 81_ MVKLL 86_ DDGTF 91_ MIPGE 96_ KVAHT 101_ SLDAL 106_ VTFHQ 111_ QKPIE 116_ PRREL 121_ LTQPC 126_ RQKDP 131_ ANVDY 136_ EDLFL 141_ YSNAV 146_ AEEAA 151_ CPVSA 156_ PEEAS 161_ PKPVL 166_ CHQSK 171_ ERKPS 176_ AEMNR 181_ ITTKE 186_ ATSSC 191_ PPKSP 196_ LGETR 201_ QKLWR 206_ SLKML 211_ PERGQ 216_ RVRQQ 221_ LKSHL 226_ ATVNL 231_ SSLLD 236_ VRRST 241_ VISGP 246_ GTGKG 251_ SQDHS 256_ GDPTS 261_ GDRGY 266_ TDPCV 271_ ATSLK 276_ SPSQP 281_ QAPKD 286_ RKVPT 291_ RKAER 296_ SVSCI 301_ EVTPG 306_ DRSWH 311_ QMVVR 316_ ALSSQ 321_ ESKPE 326_ HQGLA 331_ EPEND 336_ QLPEE 341_ YQQPP 346_PFAPG
1: May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter