E3 ubiquitin-protein ligase RNF170 (EC 2.3.2.27) (Putative LAG1-interacting protein) (RING finger protein 170) (RING-type E3 ubiquitin transferase RNF170)
1_MAKYQ 6_ GEVQS 11_ LKLDD 16_ DSVIE 21_ GVSDQ 26_ VLVAV 31_ VVSFA 36_ LIATL 41_ VYALF 46_ RNVHQ 51_ NIHPE 56_ NQELV 61_ RVLRE 66_ QLQTE 71_ QDAPA 76_ ATRQQ 81_ FYTDM 86_ YCPIC 91_ LHQAS 96_ FPVET 101_ NCGHL 106_ FCGAC 111_ IIAYW 116_ RYGSW 121_ LGAIS 126_ CPICR 131_ QTVTL 136_ LLTVF 141_ GEDDQ 146_ SQDVL 151_ RLHQD 156_ INDYN 161_ RRFSG 166_ QPRSI 171_ MERIM 176_ DLPTL 181_ LRHAF 186_ REMFS 191_ VGGLF 196_ WMFRI 201_ RIILC 206_ LMGAF 211_ FYLIS 216_ PLDFV 221_ PEALF 226_ GILGF 231_ LDDFF 236_ VIFLL 241_ LIYIS 246_ IMYRE 251_VITQR
1: E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. Selectively inhibits the TLR3-triggered innate immune response by promoting the 'Lys-48'-linked polyubiquitination and degradation of TLR3 (PubMed:31076723)