Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19)
1_MNYDS 6_ QQPPL 11_ PPLPY 16_ AGCRR 21_ ASGFP 26_ ALGRG 31_ GTVPV 36_ GVWGG 41_ AGQGR 46_ EGRSW 51_ GEGPR 56_ GPGLG 61_ RRDLS 66_ SADPA 71_ VLGAT 76_ MESRC 81_ YGCAV 86_ KFTLF 91_ KKEYG 96_ CKNCG 101_ RAFCS 106_ GCLSF 111_ SAAVP 116_ RTGNT 121_ QQKVC 126_ KQCHE 131_ VLTRG 136_ SSANA 141_ SKWSP 146_ PQNYK 151_ KRVAA 156_ LEAKQ 161_ KPSTS 166_ QSQGL 171_ TRQDQ 176_ MIAER 181_ LARLR 186_ QENKP 191_ KLVPS 196_ QAEIE 201_ ARLAA 206_ LKDER 211_ QGSIP 216_ STQEM 221_ EARLA 226_ ALQGR 231_ VLPSQ 236_ TPQPA 241_ HHTPD 246_ TRTQA 251_ QQTQD 256_ LLTQL 261_ AAEVA 266_ IDESW 271_ KGGGP 276_ AASLQ 281_ NDLNQ 286_ GGPGS 291_ TNSKR 296_ QANWS 301_ LEEEK 306_ SRLLA 311_ EAALE 316_ LREEN 321_ TRQER 326_ ILALA 331_ KRLAM 336_ LRGQD 341_ PERVT 346_ LQDYR 351_ LPDSD 356_ DDEDE 361_ ETAIQ 366_ RVLQQ 371_ LTEEA 376_ SLDEA 381_ SGFNI 386_ PAEQA 391_ SRPWT 396_ QPRGA 401_ EPEAQ 406_ DVDPR 411_ PEAEE 416_ EELPW 421_ CCICN 426_ EDATL 431_ RCAGC 436_ DGDLF 441_ CARCF 446_ REGHD 451_ AFELK 456_ EHQTS 461_ AYSPP 466_RAGQE
1: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission