RBPJ-interacting and tubulin-associated protein 1 (RBPJ-interacting and tubulin-associated protein)
1_MKTPV 6_ ELAVS 11_ GMQTL 16_ GLQHR 21_ CRGGY 26_ RVKAR 31_ TSYVD 36_ ETLFG 41_ SPAGT 46_ RPTPP 51_ DFDPP 56_ WVEKA 61_ NRTRG 66_ VGKEA 71_ SKALG 76_ AKGSC 81_ ETTPS 86_ RGSTP 91_ TLTPR 96_ KKNKY 101_ RPISH 106_ TPSYC 111_ DESLF 116_ GSRSE 121_ GASFG 126_ APRMA 131_ KGDAA 136_ KLRAL 141_ LWTPP 146_ PTPRG 151_ SHSPR 156_ PREAP 161_ LRAIH 166_ PAGPS 171_ KTEPG 176_ PAADS 181_ QKLSM 186_ GGLHS 191_ SRPLK 196_ RGLSH 201_ SLTHL 206_ NVPST 211_ GHPAT 216_ SAPHT 221_ NGPQD 226_ LRPST 231_ SGVTF 236_ RSPLV 241_ TSRAR 246_ SVSIS 251_ VPSTP 256_ RRGGA 261_TQKPK
1: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis