Potassium voltage-gated channel subfamily S member 1 (Delayed-rectifier K(+) channel alpha subunit 1) (Voltage-gated potassium channel subunit Kv9.1)
1_MLMLL 6_ VRGTH 11_ YENLR 16_ SKVVL 21_ PTPLG 26_ GRSTE 31_ TFVSE 36_ FPGPD 41_ TGIRW 46_ RRSDE 51_ ALRVN 56_ VGGVR 61_ RQLSA 66_ RALAR 71_ FPGTR 76_ LGRLQ 81_ AAASE 86_ EQARR 91_ LCDDY 96_ DEAAR 101_ EFYFD 106_ RHPGF 111_ FLSLL 116_ HFYRT 121_ GHLHV 126_ LDELC 131_ VFAFG 136_ QEADY 141_ WGLGE 146_ NALAA 151_ CCRAR 156_ YLERR 161_ LTQPH 166_ AWDED 171_ SDTPS 176_ SVDPC 181_ PDEIS 186_ DVQRE 191_ LARYG 196_ AARCG 201_ RLRRR 206_ LWLTM 211_ ENPGY 216_ SLPSK 221_ LFSCV 226_ SISVV 231_ LASIA 236_ AMCIH 241_ SLPEY 246_ QAREA 251_ AAAVA 256_ AVAAG 261_ RSPEG 266_ VRDDP 271_ VLRRL 276_ EYFCI 281_ AWFSF 286_ EVSSR 291_ LLLAP 296_ STRNF 301_ FCHPL 306_ NLIDI 311_ VSVLP 316_ FYLTL 321_ LAGVA 326_ LGDQG 331_ GKEFG 336_ HLGKV 341_ VQVFR 346_ LMRIF 351_ RVLKL 356_ ARHST 361_ GLRSL 366_ GATLK 371_ HSYRE 376_ VGILL 381_ LYLAV 386_ GVSVF 391_ SGVAY 396_ TAEKE 401_ EDVGF 406_ NTIPA 411_ CWWWG 416_ TVSMT 421_ TVGYG 426_ DVVPV 431_ TVAGK 436_ LAASG 441_ CILGG 446_ ILVVA 451_ LPITI 456_ IFNKF 461_ SHFYR 466_ RQKAL 471_ EAAVR 476_ NSNHQ 481_ EFEDL 486_ LSSID 491_ GVSEA 496_ SLETS 501_ RETSQ 506_ EGQSA 511_ DLESQ 516_ APSEP 521_PHPQM
1: Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values (PubMed:10484328). While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2 (PubMed:10484328). Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process (By similarity)