Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s)
1_MSGRG 6_ KQGGK 11_ ARAKA 16_ KTRSS 21_ RAGLQ 26_ FPVGR 31_ VHRLL 36_ RKGNY 41_ AERVG 46_ AGAPV 51_ YLAAV 56_ LEYLT 61_ AEILE 66_ LAGNA 71_ ARDNK 76_ KTRII 81_ PRHLQ 86_ LAIRN 91_ DEELN 96_ KLLGK 101_ VTIAQ 106_ GGVLP 111_ NIQAV 116_ LLPKK 121_TESHH
1: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling