Phospholipase A and acyltransferase 5 (Ca(2+)-independent N-acyltransferase) (iNAT) (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (H-rev107-like protein 5) (HRAS-like suppressor 5) (HRSL5)
1_MGLSP 6_ GAEGE 11_ YALRL 16_ PRIPP 21_ PLPKP 26_ ASRTA 31_ STGPK 36_ DQPPA 41_ LRRSA 46_ VPHSG 51_ LNSIS 56_ PLELE 61_ ESVGF 66_ AALVQ 71_ LPAKQ 76_ PPPGT 81_ LEQGR 86_ SIQQG 91_ EKAVV 96_ SLETT 101_ PSQKA 106_ DWSSI 111_ PKPEN 116_ EGKLI 121_ KQAAE 126_ GKPRP 131_ RPGDL 136_ IEIFR 141_ IGYEH 146_ WAIYV 151_ EDDCV 156_ VHLAP 161_ PSEEF 166_ EVGSI 171_ TSIFS 176_ NRAVV 181_ KYSRL 186_ EDVLH 191_ GCSWK 196_ VNNKL 201_ DGTYL 206_ PLPVD 211_ KIIQR 216_ TKKMV 221_ NKIVQ 226_ YSLIE 231_ GNCEH 236_ FVNGL 241_ RYGVP 246_ RSQQV 251_ EHALM 256_ EGAKA 261_ AGAVI 266_ SAVVD 271_SIKPK
1: Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:22825852). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19000777, PubMed:22825852)