TNFAIP3-interacting protein 3 (A20-binding inhibitor of NF-kappa-B activation 3) (ABIN-3) (Listeria-induced gene protein)
1_MAHFV 6_ QGTSR 11_ MIAAE 16_ SSTEH 21_ KECAE 26_ PSTRK 31_ NLMNS 36_ LEQKI 41_ RCLEK 46_ QRKEL 51_ LEVNQ 56_ QWDQQ 61_ FRSMK 66_ ELYER 71_ KVAEL 76_ KTKLD 81_ AAERF 86_ LSTRE 91_ KDPHQ 96_ RQRKD 101_ DRQRE 106_ DDRQR 111_ DLTRD 116_ RLQRE 121_ EKEKE 126_ RLNEE 131_ LHELK 136_ EENKL 141_ LKGKN 146_ TLANK 151_ EKEHY 156_ ECEIK 161_ RLNKA 166_ LQDAL 171_ NIKCS 176_ FSEDC 181_ LRKSR 186_ VEFCH 191_ EEMRT 196_ EMEVL 201_ KQQVQ 206_ IYEED 211_ FKKER 216_ SDRER 221_ LNQEK 226_ EELQQ 231_ INETS 236_ QSQLN 241_ RLNSQ 246_ IKACQ 251_ MEKEK 256_ LEKQL 261_ KQMYC 266_ PPCNC 271_ GLVFH 276_ LQDPW 281_ VPTGP 286_ GAVQK 291_ QREHP 296_ PDYQW 301_ YALDQ 306_ LPPDV 311_ QHKAN 316_GLSSV
1: Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding