Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a)
1_MAAAA 6_ GAAAA 11_ AAAEG 16_ EAPAE 21_ MGALL 26_ LEKET 31_ RGATE 36_ RVHGS 41_ LGDTP 46_ RSEET 51_ LPKAT 56_ PDSLE 61_ PAGPS 66_ SPASV 71_ TVTVG 76_ DEGAD 81_ TPVGA 86_ TPLIG 91_ DESEN 96_ LEGDG 101_ DLRGG 106_ RILLG 111_ HATKS 116_ FPSSP 121_ SKGGS 126_ CPSRA 131_ KMSMT 136_ GAGKS 141_ PPSVQ 146_ SLAMR 151_ LLSMP 156_ GAQGA 161_ AAAGS 166_ EPPPA 171_ TTSPE 176_ GQPKV 181_ HRARK 186_ TMSKP 191_ GNGQP 196_ PVPEK 201_ RPPEI 206_ QHFRM 211_ SDDVH 216_ SLGKV 221_ TSDLA 226_ KRRKL 231_ NSGGG 236_ LSEEL 241_ GSARR 246_ SGEVT 251_ LTKGD 256_ PGSLE 261_ EWETV 266_ VGDDF 271_ SLYYD 276_ SYSVD 281_ ERVDS 286_ DSKSE 291_ VEALT 296_ EQLSE 301_ EEEEE 306_ EEEEE 311_ EEEEE 316_ EEEEE 321_ EEEDE 326_ ESGNQ 331_ SDRSG 336_ SSGRR 341_ KAKKK 346_ WRKDS 351_ PWVKP 356_ SRKRR 361_ KREPP 366_ RAKEP 371_ RGVNG 376_ VGSSG 381_ PSEYM 386_ EVPLG 391_ SLELP 396_ SEGTL 401_ SPNHA 406_ GVSND 411_ TSSLE 416_ TERGF 421_ EELPL 426_ CSCRM 431_ EAPKI 436_ DRISE 441_ RAGHK 446_ CMATE 451_ SVDGE 456_ LSGCN 461_ AAILK 466_ RETMR 471_ PSSRV 476_ ALMVL 481_ CETHR 486_ ARMVK 491_ HHCCP 496_ GCGYF 501_ CTAGT 506_ FLECH 511_ PDFRV 516_ AHRFH 521_ KACVS 526_ QLNGM 531_ VFCPH 536_ CGEDA 541_ SEAQE 546_ VTIPR 551_ GDGVT 556_ PPAGT 561_ AAPAP 566_ PPLSQ 571_ DVPGR 576_ ADTSQ 581_ PSARM 586_ RGHGE 591_ PRRPP 596_ CDPLA 601_ DTIDS 606_ SGPSL 611_ TLPNG 616_ GCLSA 621_ VGLPL 626_ GPGRE 631_ ALEKA 636_ LVIQE 641_ SERRK 646_ KLRFH 651_ PRQLY 656_ LSVKQ 661_ GELQK 666_ VILML 671_ LDNLD 676_ PNFQS 681_ DQQSK 686_ RTPLH 691_ AAAQK 696_ GSVEI 701_ CHVLL 706_ QAGAN 711_ INAVD 716_ KQQRT 721_ PLMEA 726_ VVNNH 731_ LEVAR 736_ YMVQR 741_ GGCVY 746_ SKEED 751_ GSTCL 756_ HHAAK 761_ IGNLE 766_ MVSLL 771_ LSTGQ 776_ VDVNA 781_ QDSGG 786_ WTPII 791_ WAAEH 796_ KHIEV 801_ IRMLL 806_ TRGAD 811_ VTLTD 816_ NEENI 821_ CLHWA 826_ SFTGS 831_ AAIAE 836_ VLLNA 841_ RCDLH 846_ AVNYH 851_ GDTPL 856_ HIAAR 861_ ESYHD 866_ CVLLF 871_ LSRGA 876_ NPELR 881_ NKEGD 886_ TAWDL 891_ TPERS 896_ DVWFA 901_ LQLNR 906_ KLRLG 911_ VGNRA 916_ IRTEK 921_ IICRD 926_ VARGY 931_ ENVPI 936_ PCVNG 941_ VDGEP 946_ CPEDY 951_ KYISE 956_ NCETS 961_ TMNID 966_ RNITH 971_ LQHCT 976_ CVDDC 981_ SSSNC 986_ LCGQL 991_ SIRCW 996_ YDKDG 1001_ RLLQE 1006_ FNKIE 1011_ PPLIF 1016_ ECNQA 1021_ CSCWR 1026_ NCKNR 1031_ VVQSG 1036_ IKVRL 1041_ QLYRT 1046_ AKMGW 1051_ GVRAL 1056_ QTIPQ 1061_ GTFIC 1066_ EYVGE 1071_ LISDA 1076_ EADVR 1081_ EDDSY 1086_ LFDLD 1091_ NKDGE 1096_ VYCID 1101_ ARYYG 1106_ NISRF 1111_ INHLC 1116_ DPNII 1121_ PVRVF 1126_ MLHQD 1131_ LRFPR 1136_ IAFFS 1141_ SRDIR 1146_ TGEEL 1151_ GFDYG 1156_ DRFWD 1161_ IKSKY 1166_ FTCQC 1171_ GSEKC 1176_ KHSAE 1181_ AIALE 1186_ QSRLA 1191_ RLDPH 1196_ PELLP 1201_ELGSL
1: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself