MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1)
1_MSSRT 6_ VLAPG 11_ NDRNS 16_ DTHGT 21_ LGSGR 26_ SSDKG 31_ PSWSS 36_ RSLGA 41_ RCRNS 46_ IASCP 51_ EEQPH 56_ VGNYR 61_ LLRTI 66_ GKGNF 71_ AKVKL 76_ ARHIL 81_ TGREV 86_ AIKII 91_ DKTQL 96_ NPSSL 101_ QKLFR 106_ EVRIM 111_ KGLNH 116_ PNIVK 121_ LFEVI 126_ ETEKT 131_ LYLVM 136_ EYASA 141_ GEVFD 146_ YLVSH 151_ GRMKE 156_ KEARA 161_ KFRQI 166_ VSAVH 171_ YCHQK 176_ NIVHR 181_ DLKAE 186_ NLLLD 191_ AEANI 196_ KIADF 201_ GFSNE 206_ FTLGS 211_ KLDTF 216_ CGSPP 221_ YAAPE 226_ LFQGK 231_ KYDGP 236_ EVDIW 241_ SLGVI 246_ LYTLV 251_ SGSLP 256_ FDGHN 261_ LKELR 266_ ERVLR 271_ GKYRV 276_ PFYMS 281_ TDCES 286_ ILRRF 291_ LVLNP 296_ AKRCT 301_ LEQIM 306_ KDKWI 311_ NIGYE 316_ GEELK 321_ PYTEP 326_ EEDFG 331_ DTKRI 336_ EVMVG 341_ MGYTR 346_ EEIKE 351_ SLTSQ 356_ KYNEV 361_ TATYL 366_ LLGRK 371_ TEEGG 376_ DRGAP 381_ GLALA 386_ RVRAP 391_ SDTTN 396_ GTSSS 401_ KGTSH 406_ SKGQR 411_ SSSST 416_ YHRQR 421_ RHSDF 426_ CGPSP 431_ APLHP 436_ KRSPT 441_ STGEA 446_ ELKEE 451_ RLPGR 456_ KASCS 461_ TAGSG 466_ SRGLP 471_ PSSPM 476_ VSSAH 481_ NPNKA 486_ EIPER 491_ RKDST 496_ STPNN 501_ LPPSM 506_ MTRRN 511_ TYVCT 516_ ERPGA 521_ ERPSL 526_ LPNGK 531_ ENSSG 536_ TPRVP 541_ PASPS 546_ SHSLA 551_ PPSGE 556_ RSRLA 561_ RGSTI 566_ RSTFH 571_ GGQVR 576_ DRRAG 581_ GGGGG 586_ GVQNG 591_ PPASP 596_ TLAHE 601_ AAPLP 606_ AGRPR 611_ PTTNL 616_ FTKLT 621_ SKLTR 626_ RVADE 631_ PERIG 636_ GPEVT 641_ SCHLP 646_ WDQTE 651_ TAPRL 656_ LRFPW 661_ SVKLT 666_ SSRPP 671_ EALMA 676_ ALRQA 681_ TAAAR 686_ CRCRQ 691_ PQPFL 696_ LACLH 701_ GGAGG 706_ PEPLS 711_ HFEVE 716_ VCQLP 721_ RPGLR 726_ GVLFR 731_ RVAGT 736_ ALAFR 741_ TLVTR 746_ISNDL
1: Serine/threonine-protein kinase (PubMed:14594945, PubMed:15009667, PubMed:23184942, PubMed:23666762). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979)