Leucine-rich repeat protein 1 (4-1BB-mediated-signaling molecule) (4-1BBlrr) (LRR-repeat protein 1) (LRR-1) (Peptidylprolyl isomerase-like 5)
1_MKLHC 6_ EVEVI 11_ SRHLP 16_ ALGLR 21_ NRGKG 26_ VRAVL 31_ SLCQQ 36_ TSRSQ 41_ PPVRA 46_ FLLIS 51_ TLKDK 56_ RGTRY 61_ ELREN 66_ IEQFF 71_ TKFVD 76_ EGKAT 81_ VRLKE 86_ PPVDI 91_ CLSKA 96_ ISSSL 101_ KGFLS 106_ AMRLA 111_ HRGCN 116_ VDTPV 121_ STLTP 126_ VKTSE 131_ FENFK 136_ TKMVI 141_ TSKKD 146_ YPLSK 151_ NFPYS 156_ LEHLQ 161_ TSYCG 166_ LVRVD 171_ MRMLC 176_ LKSLR 181_ KLDLS 186_ HNHIK 191_ KLPAT 196_ IGDLI 201_ HLQEL 206_ NLNDN 211_ HLESF 216_ SVALC 221_ HSTLQ 226_ KSLRS 231_ LDLSK 236_ NKIKA 241_ LPVQF 246_ CQLQE 251_ LKNLK 256_ LDDNE 261_ LIQFP 266_ CKIGQ 271_ LINLR 276_ FLSAA 281_ RNKLP 286_ FLPSE 291_ FRNLS 296_ LEYLD 301_ LFGNT 306_ FEQPK 311_ VLPVI 316_ KLQAP 321_ LTLLE 326_ SSART 331_ ILHNR 336_ IPYGS 341_ HIIPF 346_ HLCQD 351_ LDTAK 356_ ICVCG 361_ RFCLN 366_ SFIQG 371_ TTTMN 376_ LHSVA 381_ HTVVL 386_ VDNLG 391_ GTEAP 396_ IISYF 401_ CSLGC 406_YVNSS
1: Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1 (PubMed:11804328)