Sorting nexin-27
1_MADED 6_ GEGIH 11_ PSAPH 16_ RNGGG 21_ GGGGG 26_ SGLHC 31_ AGNGG 36_ GGGGG 41_ PRVVR 46_ IVKSE 51_ SGYGF 56_ NVRGQ 61_ VSEGG 66_ QLRSI 71_ NGELY 76_ APLQH 81_ VSAVL 86_ PGGAA 91_ DRAGV 96_ RKGDR 101_ ILEVN 106_ HVNVE 111_ GATHK 116_ QVVDL 121_ IRAGE 126_ KELIL 131_ TVLSV 136_ PPHEA 141_ DNLDP 146_ SDDSL 151_ GQSFY 156_ DYTEK 161_ QAVPI 166_ SVPRY 171_ KHVEQ 176_ NGEKF 181_ VVYNV 186_ YMAGR 191_ QLCSK 196_ RYREF 201_ AILHQ 206_ NLKRE 211_ FANFT 216_ FPRLP 221_ GKWPF 226_ SLSEQ 231_ QLDAR 236_ RRGLE 241_ EYLEK 246_ VCSIR 251_ VIGES 256_ DIMQE 261_ FLSES 266_ DENYN 271_ GVSDV 276_ ELRVA 281_ LPDGT 286_ TVTVR 291_ VKKNS 296_ TTDQV 301_ YQAIA 306_ AKVGM 311_ DSTTV 316_ NYFAL 321_ FEVIS 326_ HSFVR 331_ KLAPN 336_ EFPHK 341_ LYIQN 346_ YTSAV 351_ PGTCL 356_ TIRKW 361_ LFTTE 366_ EEILL 371_ NDNDL 376_ AVTYF 381_ FHQAV 386_ DDVKK 391_ GYIKA 396_ EEKSY 401_ QLQKL 406_ YEQRK 411_ MVMYL 416_ NMLRT 421_ CEGYN 426_ EIIFP 431_ HCACD 436_ SRRKG 441_ HVITA 446_ ISITH 451_ FKLHA 456_ CTEEG 461_ QLENQ 466_ VIAFE 471_ WDEMQ 476_ RWDTD 481_ EEGMA 486_ FCFEY 491_ ARGEK 496_ KPRWV 501_ KIFTP 506_ YFNYM 511_ HECFE 516_ RVFCE 521_ LKWRK 526_ ENIFQ 531_ MARSQ 536_QRDVA
1: Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes