Gene name: FCRL1

Uniprot entry:

Q96LA6

Protein names:

Fc receptor-like protein 1 (FcR-like protein 1) (FcRL1) (Fc receptor homolog 1) (FcRH1) (IFGP family protein 1) (hIFGP1) (Immune receptor translocation-associated protein 5) (CD antigen CD307a)

Protein sequence:

1_MLPRL 6_ LLLIC 11_ APLCE 16_ PAELF 21_ LIASP 26_ SHPTE 31_ GSPVT 36_ LTCKM 41_ PFLQS 46_ SDAQF 51_ QFCFF 56_ RDTRA 61_ LGPGW 66_ SSSPK 71_ LQIAA 76_ MWKED 81_ TGSYW 86_ CEAQT 91_ MASKV 96_ LRSRR 101_ SQINV 106_ HRVPV 111_ ADVSL 116_ ETQPP 121_ GGQVM 126_ EGDRL 131_ VLICS 136_ VAMGT 141_ GDITF 146_ LWYKG 151_ AVGLN 156_ LQSKT 161_ QRSLT 166_ AEYEI 171_ PSVRE 176_ SDAEQ 181_ YYCVA 186_ ENGYG 191_ PSPSG 196_ LVSIT 201_ VRIPV 206_ SRPIL 211_ MLRAP 216_ RAQAA 221_ VEDVL 226_ ELHCE 231_ ALRGS 236_ PPILY 241_ WFYHE 246_ DITLG 251_ SRSAP 256_ SGGGA 261_ SFNLS 266_ LTEEH 271_ SGNYS 276_ CEANN 281_ GLGAQ 286_ RSEAV 291_ TLNFT 296_ VPTGA 301_ RSNHL 306_ TSGVI 311_ EGLLS 316_ TLGPA 321_ TVALL 326_ FCYGL 331_ KRKIG 336_ RRSAR 341_ DPLRS 346_ LPSPL 351_ PQEFT 356_ YLNSP 361_ TPGQL 366_ QPIYE 371_ NVNVV 376_ SGDEV 381_ YSLAY 386_ YNQPE 391_ QESVA 396_ AETLG 401_ THMED 406_ KVSLD 411_ IYSRL 416_ RKANI 421_TDVDY

Protein annotations

Protein functions:

1: Type I transmembrane surface glycoprotein preferentially expressed by B-cells that regulates BCR-mediated signaling responses (PubMed:15479727). Recruits ABL1 as the intracellular effector molecule to enhance B-cell activation (By similarity). Also plays a negative role by suppressing ERK activation under homeostatic and BCR-stimulated conditions in a GRB2-dependent manner (By similarity)