CCR4-NOT transcription complex subunit 6-like (EC 3.1.13.4) (Carbon catabolite repressor protein 4 homolog B)
1_MRLIG 6_ MPKEK 11_ YDPPD 16_ PRRIY 21_ TIMSA 26_ EEVAN 31_ GKKSH 36_ WAELE 41_ ISGRV 46_ RSLST 51_ SLWSL 56_ THLTA 61_ LHLND 66_ NYLSR 71_ IPPDI 76_ AKLHN 81_ LVYLD 86_ LSSNK 91_ LRSLP 96_ AELGN 101_ MVSLR 106_ ELLLN 111_ NNLLR 116_ VLPYE 121_ LGRLF 126_ QLQTL 131_ GLKGN 136_ PLSQD 141_ ILNLY 146_ QDPDG 151_ TRKLL 156_ NFMLD 161_ NLAVH 166_ PEQLP 171_ PRPWI 176_ TLKER 181_ DQILP 186_ SASFT 191_ VMCYN 196_ VLCDK 201_ YATRQ 206_ LYGYC 211_ PSWAL 216_ NWEYR 221_ KKGIM 226_ EEIVN 231_ CDADI 236_ ISLQE 241_ VETEQ 246_ YFTLF 251_ LPALK 256_ ERGYD 261_ GFFSP 266_ KSRAK 271_ IMSEQ 276_ ERKHV 281_ DGCAI 286_ FFKTE 291_ KFTLV 296_ QKHTV 301_ EFNQV 306_ AMANS 311_ DGSEA 316_ MLNRV 321_ MTKDN 326_ IGVAV 331_ VLEVH 336_ KELFG 341_ AGMKP 346_ IHAAD 351_ KQLLI 356_ VANAH 361_ MHWDP 366_ EYSDV 371_ KLIQT 376_ MMFVS 381_ EVKNI 386_ LEKAS 391_ SRPGS 396_ PTADP 401_ NSIPL 406_ VLCAD 411_ LNSLP 416_ DSGVV 421_ EYLSN 426_ GGVAD 431_ NHKDF 436_ KELRY 441_ NECLM 446_ NFSCN 451_ GKNGS 456_ SEGRI 461_ THGFQ 466_ LKSAY 471_ ENNLM 476_ PYTNY 481_ TFDFK 486_ GVIDY 491_ IFYSK 496_ THMNV 501_ LGVLG 506_ PLDPQ 511_ WLVEN 516_ NITGC 521_ PHPHI 526_ PSDHF 531_ SLLTQ 536_ LELHP 541_ PLLPL 546_VNGVH
1: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence