Centrosomal protein of 19 kDa (Cep19)
1_MMCTA 6_ KKCGI 11_ RFQPP 16_ AIILI 21_ YESEI 26_ KGKIR 31_ QRIMP 36_ VRNFS 41_ KFSDC 46_ TRAAE 51_ QLKNN 56_ PRHKS 61_ YLEQV 66_ SLRQL 71_ EKLFS 76_ FLRGY 81_ LSGQS 86_ LAETM 91_ EQIQR 96_ ETTID 101_ PEEDL 106_ NKLDD 111_ KELAK 116_ RKSIM 121_ DELFE 126_ KNQKK 131_ KDDPN 136_ FVYDI 141_ EVEFP 146_ QDDQL 151_ QSCGW 156_DTESA
1: Required for ciliation (PubMed:28428259, PubMed:28625565, PubMed:28659385). Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia (PubMed:28428259, PubMed:28625565). Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes (PubMed:28659385)