Leucine rich adaptor protein 1 (Leucine repeat adapter protein 35A)
1_MEGTV 6_ ESQTP 11_ DLRDV 16_ EGKVG 21_ RKTPE 26_ GLLRG 31_ LRGEC 36_ ELGTS 41_ GALLL 46_ PGASS 51_ TGHDL 56_ GDKIM 61_ ALKME 66_ LAYLR 71_ AIDVK 76_ ILQQL 81_ VTLNE 86_ GIEAV 91_ RWLLE 96_ ERGTL 101_ TSHCS 106_ SLTSS 111_ QYSLT 116_ GGSPG 121_ RSRRG 126_ SWDSL 131_ PDTST 136_ TDRLD 141_ SVSIG 146_ SFLDT 151_ VAPSE 156_ LDEQG 161_ PPGAP 166_ RSEMD 171_ WAKVI 176_ AGGER 181_ ARTEV 186_ DVAAT 191_ RLGSL 196_ RAVWK 201_ PPGER 206_ LQGGP 211_ PESPE 216_ DESAK 221_ LGFEA 226_ HWFWE 231_QCQDD
1: Acts as an activator of the canonical NF-kappa-B pathway and drive the production of pro-inflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity)