Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2)
1_MSTEA 6_ QRVDD 11_ SPSTS 16_ GGSSD 21_ GDQRE 26_ SVQQE 31_ PEREQ 36_ VQPKK 41_ KEGKI 46_ SSKTA 51_ AKLST 56_ SAKRI 61_ QKELA 66_ EITLD 71_ PPPNC 76_ SAGPK 81_ GDNIY 86_ EWRST 91_ ILGPP 96_ GSVYE 101_ GGVFF 106_ LDITF 111_ SPDYP 116_ FKPPK 121_ VTFRT 126_ RIYHC 131_ NINSQ 136_ GVICL 141_ DILKD 146_ NWSPA 151_ LTISK 156_ VLLSI 161_ CSLLT 166_ DCNPA 171_ DPLVG 176_ SIATQ 181_ YMTNR 186_ AEHDR 191_ MARQW 196_TKRYA
1: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein