(E2-independent) E3 ubiquitin-conjugating enzyme FATS (EC 2.3.2.-) (Centrosomal protein C10orf90) (E2/E3 hybrid ubiquitin-protein ligase FATS) (Fragile-site associated tumor suppressor homolog) (FATS)
1_MLKLS 6_ GEGLR 11_ DSYHS 16_ RRDQI 21_ ALKNL 26_ QSDVT 31_ EAKSD 36_ FTKET 41_ LASQN 46_ TKMIS 51_ SIVIS 56_ QMIDE 61_ NKSRE 66_ NRASL 71_ PLPCA 76_ IAQSR 81_ AHHAK 86_ QSLAN 91_ RSGVN 96_ IHRAF 101_ ALLPG 106_ RLGIP 111_ APSDE 116_ RGPEA 121_ ELPPK 126_ EERPC 131_ GGPRR 136_ GFASI 141_ TITAR 146_ RVGPP 151_ ARALV 156_ WGTAG 161_ DSLCP 166_ KCRAE 171_ DTLFQ 176_ APPAL 181_ ANGAH 186_ PGRHQ 191_ RSFAC 196_ TEFSR 201_ NSSVV 206_ RLKVP 211_ EAHTG 216_ LCERR 221_ KYWVT 226_ HADDK 231_ ETSFS 236_ PDTPL 241_ SGKSP 246_ LVFSS 251_ CVHLR 256_ VSQQC 261_ PDSIY 266_ YVDKS 271_ LSVPI 276_ EPPQI 281_ ASPKM 286_ HRSVL 291_ SLNLN 296_ CSSHR 301_ LTADG 306_ VDGLV 311_ NREPI 316_ SEALK 321_ QELLE 326_ GDQDL 331_ VGQRW 336_ NPGLQ 341_ ESHLK 346_ ETPSL 351_ RRVHL 356_ GTGAC 361_ PWSGS 366_ FPLEN 371_ TELAN 376_ VGANQ 381_ VTVRK 386_ GEKDH 391_ TTHCH 396_ ASDHA 401_ NQLSI 406_ HIPGW 411_ SYRAV 416_ HTKVF 421_ SGSSK 426_ RQQGE 431_ VCMTV 436_ SAPPV 441_ EQKPT 446_ RHFLP 451_ IGDSS 456_ PSDDC 461_ LSRDL 466_ SEPTE 471_ RRHQS 476_ FLKPR 481_ ILFPG 486_ FLCPL 491_ QDVCA 496_ SLQED 501_ NGVQI 506_ ESKFP 511_ KGDYT 516_ CCDLV 521_ VKIKE 526_ CKKSE 531_ DPTTP 536_ EPSPA 541_ APSPA 546_ PRDGA 551_ GSPGL 556_ SEDCS 561_ ESQQT 566_ PARSL 571_ TLQEA 576_ LEVRK 581_ PQFIS 586_ RSQER 591_ LKKLE 596_ HMVQQ 601_ RKAQR 606_ KEDLR 611_ QKQSL 616_ LPIRT 621_ SKKQF 626_ TIPHP 631_ LSDNL 636_ FKPKE 641_ RCISE 646_ KEMHM 651_ RSKRI 656_ YDNLP 661_ EVKKK 666_ KEEQR 671_ KRVIL 676_ QSNRL 681_ RAEVF 686_ KKQLL 691_DQLLQ
1: Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (By similarity). May have a role in the assembly of primary cilia (Probable)