Parkin coregulated gene protein (Molecular chaperone/chaperonin-binding protein) (PARK2 coregulated gene protein)
1_MVAEK 6_ ETLSL 11_ NKCPD 16_ KMPKR 21_ TKLLA 26_ QQPLP 31_ VHQPH 36_ SLVSE 41_ GFTVK 46_ AMMKN 51_ SVVRG 56_ PPAAG 61_ AFKER 66_ PTKPT 71_ AFRKF 76_ YERGD 81_ FPIAL 86_ EHDSK 91_ GNKIA 96_ WKVEI 101_ EKLDY 106_ HHYLP 111_ LFFDG 116_ LCEMT 121_ FPYEF 126_ FARQG 131_ IHDML 136_ EHGGN 141_ KILPV 146_ LPQLI 151_ IPIKN 156_ ALNLR 161_ NRQVI 166_ CVTLK 171_ VLQHL 176_ VVSAE 181_ MVGKA 186_ LVPYY 191_ RQILP 196_ VLNIF 201_ KNMNG 206_ SYSLP 211_ RLECS 216_ GAIMA 221_ RCNLD 226_ HLGSS 231_ DPPTS 236_ ASQVA 241_ EIIVN 246_ SGDGI 251_ DYSQQ 256_ KRENI 261_ GDLIQ 266_ ETLEA 271_ FERYG 276_ GENAF 281_ INIKY 286_ VVPTY 291_ESCLL
1: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin) (PubMed:14532270). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited (PubMed:14532270). May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease (PubMed:14532270)