Gene name: DRC1

Uniprot entry:

Q96MC2

Protein names:

Dynein regulatory complex protein 1 (Coiled-coil domain-containing protein 164)

Protein sequence:

1_MNPPG 6_ SLEAL 11_ DPNVD 16_ EHLST 21_ QILAP 26_ SVHSD 31_ NSQER 36_ IQARR 41_ LRIAA 46_ RLEAR 51_ RREAL 56_ GEYLD 61_ GKKES 66_ EEDQS 71_ KSYKQ 76_ KEESR 81_ LKLAK 86_ LLLCG 91_ TELVT 96_ NIQVA 101_ IDIRE 106_ IHRRV 111_ EEEEI 116_ KRQRI 121_ EKLEN 126_ EVKTS 131_ QDKFD 136_ EITSK 141_ WEEGK 146_ QKRIP 151_ QELWE 156_ MLNTQ 161_ QLHCA 166_ GLLED 171_ KNKLI 176_ SELQQ 181_ ELKTK 186_ DDQYV 191_ KDLKK 196_ QSDDI 201_ CLLLE 206_ RMEEQ 211_ VKNVM 216_ KTFRE 221_ ELYNI 226_ EKAFE 231_ VERQE 236_ LLASN 241_ KKKWE 246_ QALQA 251_ HNAKE 256_ LEYLN 261_ NRMKK 266_ VEDYE 271_ KQLNR 276_ QRIWD 281_ CEEYN 286_ MIKIK 291_ LEQDV 296_ QILEQ 301_ QLQQR 306_ KAIYQ 311_ LNQEK 316_ LEYNL 321_ QVLKK 326_ RDEES 331_ TVIKS 336_ QQKRK 341_ INRLH 346_ DILNN 351_ LRSKY 356_ AKQIK 361_ QFQEE 366_ NQSLT 371_ SDYKR 376_ LVMQF 381_ KELQK 386_ AMRHF 391_ ALIDD 396_ EKFWE 401_ IWLMN 406_ EEEAK 411_ DLIAR 416_ AFDVD 421_ RIIHT 426_ HHLGL 431_ PWAAP 436_ DFWFL 441_ NNVGP 446_ ISQQP 451_ QKSAT 456_ QIVEE 461_ MLMRS 466_ EEEEA 471_ EEAAA 476_ EPESY 481_ LDLPK 486_ QISEK 491_ TTKRI 496_ LMLLC 501_ DESGF 506_ LIESK 511_ LLSLL 516_ LPLEQ 521_ NECYL 526_ LRLDA 531_ IFSAL 536_ GIESE 541_ DDLYK 546_ LVNFF 551_ LKYRA 556_ HRLSS 561_ SLQIK 566_ PCSQA 571_ SMEKA 576_ SMEET 581_ STRSE 586_ LELAE 591_ QTEME 596_ GEKEE 601_ SLVEG 606_ EKEEE 611_ EETPP 616_ SPWVI 621_ HPNDV 626_ LKILE 631_ AFVMG 636_ LKKPR 641_ DSRAP 646_ LRVQK 651_ NVRDN 656_ SKDSE 661_ YWQAL 666_ TTVIP 671_ SSKQN 676_ LWDAL 681_ YTALE 686_ KYHLV 691_ LTQRA 696_ KLLLE 701_ NSSLE 706_ QQNTE 711_ LQALL 716_ QQYLN 721_ SKINS 726_ ELQVP 731_PTQVL

Protein annotations

Protein functions:

1: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes (PubMed:23354437, PubMed:34169321). Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:23354437)