KICSTOR subunit 2 (KICSTOR complex protein C12orf66)
1_MGESI 6_ PLAAP 11_ VPVEQ 16_ AVLET 21_ FFSHL 26_ GIFSY 31_ DKAKD 36_ NVEKE 41_ REANK 46_ SAGGS 51_ WLSLL 56_ AALAH 61_ LAAAE 66_ KVYHS 71_ LTYLG 76_ QKLGG 81_ QSFFS 86_ RKDSI 91_ RTIYT 96_ SLHNE 101_ LKKVV 106_ TGRGA 111_ LGGTA 116_ PHVEE 121_ LLSHL 126_ SEQLC 131_ FFVQA 136_ RMEIA 141_ DFYEK 146_ MYTLS 151_ TQKFI 156_ NAEEL 161_ VGLLD 166_ AIMKK 171_ YSSRF 176_ HHPIL 181_ SPLES 186_ SFQLE 191_ VDVLC 196_ HLLKA 201_ QAQVS 206_ EWKFL 211_ PSLVN 216_ LHSAH 221_ TKLQT 226_ WGQIF 231_ EKQRE 236_ TKKHL 241_ FGGQS 246_ QKAVQ 251_ PPHLF 256_ LWLMK 261_ LKNML 266_ LAKFS 271_ FYFHE 276_ ALSRQ 281_ TTASE 286_ MKTLT 291_ AKANP 296_ DFFGK 301_ ISSFI 306_ RKYDA 311_ ANVSL 316_ IFDNR 321_ GSESF 326_ QGHGY 331_ HHPHS 336_ YREAP 341_ KGVDQ 346_ YPAVV 351_ SLPSD 356_ RPVMH 361_ WPNVI 366_ MIMTD 371_ RTSDL 376_ NSLEK 381_ VVHFY 386_ DDKVQ 391_ STYFL 396_ TRPEP 401_ HFTIV 406_ IIFES 411_ KKSER 416_ DSHFI 421_ SFLNE 426_ VSLAL 431_ KNPKV 436_FASLK
1: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose