E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog)
1_MPGRS 6_ SSNSG 11_ STGFI 16_ SFSGV 21_ ESALS 26_ SLKNF 31_ QACIN 36_ SGMDT 41_ ASSVA 46_ LDLVE 51_ SQTEV 56_ SSEYS 61_ MDKAM 66_ VEFAT 71_ LDRQL 76_ NHYVK 81_ AVQST 86_ INHVK 91_ EERPE 96_ KIPDL 101_ KLLVE 106_ KKFLA 111_ LQSKN 116_ SDADF 121_ QNNEK 126_ FVQFK 131_ QQLKE 136_ LKKQC 141_ GLQAD 146_ READG 151_ TEGVD 156_ EDIIV 161_ TQSQT 166_ NFTCP 171_ ITKEE 176_ MKKPV 181_ KNKVC 186_ GHTYE 191_ EDAIV 196_ RMIES 201_ RQKRK 206_ KKAYC 211_ PQIGC 216_ SHTDI 221_ RKSDL 226_ IQDEA 231_ LRRAI 236_ ENHNK 241_KRHRH
1: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination (PubMed:16055714, PubMed:16810316). Is not be required for the stability of the complex (PubMed:16055714, PubMed:16810316). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks (PubMed:16055714, PubMed:16810316). The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) (PubMed:17589526). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2 (PubMed:16055714, PubMed:16810316, PubMed:17589526, PubMed:31400850). Required for recruitment of telomeres to PML nuclear bodies (PubMed:17589526). SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines (PubMed:17589526). Required for sister chromatid cohesion during prometaphase and mitotic progression (PubMed:19502785)