Junctional sarcoplasmic reticulum protein 1 (Junctional-face membrane protein of 45 kDa homolog) (JP-45)
1_MSMTT 6_ RAWEE 11_ LDGGL 16_ GSCQA 21_ LEDHS 26_ ALAET 31_ QEDRA 36_ SATPR 41_ LADSG 46_ SVPHD 51_ SQVAE 56_ GPSVD 61_ TRPKK 66_ MEKEP 71_ AARGT 76_ PGTGK 81_ ERLKA 86_ GASPR 91_ SVPAR 96_ KKAQT 101_ APPLQ 106_ PPPPP 111_ PALSE 116_ ELPWG 121_ DLSLN 126_ KCLVL 131_ ASLVA 136_ LLGSA 141_ FQLCR 146_ DAVPG 151_ EAALQ 156_ ARVPE 161_ PWVPP 166_ SSAPR 171_ EPSSP 176_ LPKFE 181_ AQAPP 186_ SAPPA 191_ PRAEA 196_ EVRPK 201_ IPGSR 206_ EAAEN 211_ DEEEP 216_ GEATG 221_ EAVRE 226_ DRVTL 231_ ADRGP 236_ KERPR 241_ REGKP 246_ RKEKP 251_ RKEER 256_ PKKER 261_ PRKEE 266_ RPRAA 271_ REPRE 276_ ALPQR 281_ WESRE 286_ GGHRP 291_ WARDS 296_ RDAEP 301_ RKKQA 306_ WVSPR 311_ RPDEE 316_ QRPGS 321_ RQKLR 326_AGKGR
1: Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity