Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2)
1_MLQKP 6_ RNRGR 11_ SGGQA 16_ ERDRD 21_ WSHSG 26_ NPGAS 31_ RAGED 36_ ARVLR 41_ DGFAE 46_ EAPST 51_ SRGPG 56_ GSQGS 61_ QGPSP 66_ QGARR 71_ AQAAP 76_ AVGPR 81_ SQKQL 86_ ELKVS 91_ ELVQF 96_ LLIKD 101_ QKKIP 106_ IKRAD 111_ ILKHV 116_ IGDYK 121_ DIFPD 126_ LFKRA 131_ AERLQ 136_ YVFGY 141_ KLVEL 146_ EPKSN 151_ TYILI 156_ NTLEP 161_ VEEDA 166_ EMRGD 171_ QGTPT 176_ TGLLM 181_ IVLGL 186_ IFMKG 191_ NTIKE 196_ TEAWD 201_ FLRRL 206_ GVYPT 211_ KKHLI 216_ FGDPK 221_ KLITE 226_ DFVRQ 231_ RYLEY 236_ RRIPH 241_ TDPVD 246_ YEFQW 251_ GPRTN 256_ LETSK 261_ MKVLK 266_ FVAKV 271_ HNQDP 276_ KDWPA 281_ QYCEA 286_ LADEE 291_ NRARP 296_QPSGP
1: Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity)