Protein-L-isoaspartate O-methyltransferase domain-containing protein 1
1_MGGAV 6_ SAGED 11_ NDDLI 16_ DNLKE 21_ AQYIR 26_ TERVE 31_ QAFRA 36_ IDRGD 41_ YYLEG 46_ YRDNA 51_ YKDLA 56_ WKHGN 61_ IHLSA 66_ PCIYS 71_ EVMEA 76_ LKLQP 81_ GLSFL 86_ NLGSG 91_ TGYLS 96_ TMVGL 101_ ILGPF 106_ GINHG 111_ IELHS 116_ DVVEY 121_ AKEKL 126_ ESFIK 131_ NSDSF 136_ DKFEF 141_ CEPAF 146_ VVGNC 151_ LQIAS 156_ DSHQY 161_ DRIYC 166_ GAGVQ 171_ KDHEN 176_ YMKIL 181_ LKVGG 186_ ILVMP 191_ IEDQL 196_ TQIMR 201_ TGQNT 206_ WESKN 211_ ILAVS 216_ FAPLV 221_ QPSKN 226_ DNGKP 231_ DSVGL 236_ PPCAV 241_ RNLQD 246_ LARIY 251_ IRRTL 256_ RNFIN 261_ DEMQA 266_ KGIPQ 271_ RAPPK 276_ RKRKR 281_ VKQRI 286_ NTYVF 291_ VGNQL 296_ IPQPL 301_ DSEED 306_ EKMEE 311_ DNKEE 316_ EEKDH 321_ NEAMK 326_ PEEPP 331_ QNLLR 336_ EKIMK 341_ LPLPE 346_ SLKAY 351_LTYFR
1: Substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:35486881). Specifically binds to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but does not display methyltransferase activity (PubMed:35486881). May provide an alternate maintenance pathway for modified proteins by acting as a damage-specific E3 ubiquitin ligase adaptor protein (PubMed:35486881)