Transmembrane protein 68
1_MIDKN 6_ QTCGV 11_ GQDSV 16_ PYMIC 21_ LIHIL 26_ EEWFG 31_ VEQLE 36_ DYLNF 41_ ANYLL 46_ WVFTP 51_ LILLI 56_ LPYFT 61_ IFLLY 66_ LTIIF 71_ LHIYK 76_ RKNVL 81_ KEAYS 86_ HNLWD 91_ GARKT 96_ VATLW 101_ DGHAA 106_ VWHGY 111_ EVHGM 116_ EKIPE 121_ DGPAL 126_ IIFYH 131_ GAIPI 136_ DFYYF 141_ MAKIF 146_ IHKGR 151_ TCRVV 156_ ADHFV 161_ FKIPG 166_ FSLLL 171_ DVFCA 176_ LHGPR 181_ EKCVE 186_ ILRSG 191_ HLLAI 196_ SPGGV 201_ REALI 206_ SDETY 211_ NIVWG 216_ HRRGF 221_ AQVAI 226_ DAKVP 231_ IIPMF 236_ TQNIR 241_ EGFRS 246_ LGGTR 251_ LFRWL 256_ YEKFR 261_ YPFAP 266_ MYGGF 271_ PVKLR 276_ TYLGD 281_ PIPYD 286_ PQITA 291_ EELAE 296_ KTKNA 301_ VQALI 306_ DKHQR 311_ IPGNI 316_MSALL
1: Catalytic subunit of the alternative triglyceride biosynthesis pathway, which mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (PubMed:37648867). Synthesizes triacylglycerol at the expense of membrane phospholipids, such as phosphatidylcholine (PC) and its ether-linked form (ePC), thereby altering the composition of membranes (PubMed:37648867). The alternative triglyceride biosynthesis pathway is probably required to provide the energy required for rapid growth when fuel sources are limiting (PubMed:37648867). It maintains mitochondrial function during periods of extracellular lipid starvation (PubMed:37648867). Can also use acyl-CoA as donor: acts as a acyl-CoA:monoacylglycerol acyltransferase (MGAT), but also shows acyl-CoA:diacylglycerol acyltransferase (DGAT) activity (By similarity)