NACHT, LRR and PYD domains-containing protein 4 (Cancer/testis antigen 58) (CT58) (PAAD and NACHT-containing protein 2) (PAN2) (PYRIN and NACHT-containing protein 2) (PYRIN-containing APAF1-like protein 4) (PYPAF4) (Ribonuclease inhibitor 2)
1_MAASF 6_ FSDFG 11_ LMWYL 16_ EELKK 21_ EEFRK 26_ FKEHL 31_ KQMTL 36_ QLELK 41_ QIPWT 46_ EVKKA 51_ SREEL 56_ ANLLI 61_ KHYEE 66_ QQAWN 71_ ITLRI 76_ FQKMD 81_ RKDLC 86_ MKVMR 91_ ERTGY 96_ TKTYQ 101_ AHAKQ 106_ KFSRL 111_ WSSKS 116_ VTEIH 121_ LYFEE 126_ EVKQE 131_ ECDHL 136_ DRLFA 141_ PKEAG 146_ KQPRT 151_ VIIQG 156_ PQGIG 161_ KTTLL 166_ MKLMM 171_ AWSDN 176_ KIFRD 181_ RFLYT 186_ FYFCC 191_ RELRE 196_ LPPTS 201_ LADLI 206_ SREWP 211_ DPAAP 216_ ITEIV 221_ SQPER 226_ LLFVI 231_ DSFEE 236_ LQGGL 241_ NEPDS 246_ DLCGD 251_ LMEKR 256_ PVQVL 261_ LSSLL 266_ RKKML 271_ PEASL 276_ LIAIK 281_ PVCPK 286_ ELRDQ 291_ VTISE 296_ IYQPR 301_ GFNES 306_ DRLVY 311_ FCCFF 316_ KDPKR 321_ AMEAF 326_ NLVRE 331_ SEQLF 336_ SICQI 341_ PLLCW 346_ ILCTS 351_ LKQEM 356_ QKGKD 361_ LALTC 366_ QSTTS 371_ VYSSF 376_ VFNLF 381_ TPEGA 386_ EGPTP 391_ QTQHQ 396_ LKALC 401_ SLAAE 406_ GMWTD 411_ TFEFC 416_ EDDLR 421_ RNGVV 426_ DADIP 431_ ALLGT 436_ KILLK 441_ YGERE 446_ SSYVF 451_ LHVCI 456_ QEFCA 461_ ALFYL 466_ LKSHL 471_ DHPHP 476_ AVRCV 481_ QELLV 486_ ANFEK 491_ ARRAH 496_ WIFLG 501_ CFLTG 506_ LLNKK 511_ EQEKL 516_ DAFFG 521_ FQLSQ 526_ EIKQQ 531_ IHQCL 536_ KSLGE 541_ RGNPQ 546_ GQVDS 551_ LAIFY 556_ CLFEM 561_ QDPAF 566_ VKQAV 571_ NLLQE 576_ ANFHI 581_ IDNVD 586_ LVVSA 591_ YCLKY 596_ CSSLR 601_ KLCFS 606_ VQNVF 611_ KKEDE 616_ HSSTS 621_ DYSLI 626_ CWHHI 631_ CSVLT 636_ TSGHL 641_ RELQV 646_ QDSTL 651_ SESTF 656_ VTWCN 661_ QLRHP 666_ SCRLQ 671_ KLGIN 676_ NVSFS 681_ GQSVL 686_ LFEVL 691_ FYQPD 696_ LKYLS 701_ FTLTK 706_ LSRDD 711_ IRSLC 716_ DALNY 721_ PAGNV 726_ KELAL 731_ VNCHL 736_ SPIDC 741_ EVLAG 746_ LLTNN 751_ KKLTY 756_ LNVSC 761_ NQLDT 766_ GVPLL 771_ CEALC 776_ SPDTV 781_ LVYLM 786_ LAFCH 791_ LSEQC 796_ CEYIS 801_ EMLLR 806_ NKSVR 811_ YLDLS 816_ ANVLK 821_ DEGLK 826_ TLCEA 831_ LKHPD 836_ CCLDS 841_ LCLVK 846_ CFITA 851_ AGCED 856_ LASAL 861_ ISNQN 866_ LKILQ 871_ IGCNE 876_ IGDVG 881_ VQLLC 886_ RALTH 891_ TDCRL 896_ EILGL 901_ EECGL 906_ TSTCC 911_ KDLAS 916_ VLTCS 921_ KTLQQ 926_ LNLTL 931_ NTLDH 936_ TGVVV 941_ LCEAL 946_ RHPEC 951_ ALQVL 956_ GLRKT 961_ DFDEE 966_ TQALL 971_ TAEEE 976_ RNPNL 981_ TITDD 986_CDTIT
1: May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways