Centrosomal protein of 63 kDa (Cep63)
1_MEALL 6_ EGIQN 11_ RGHGG 16_ GFLTS 21_ CEAEL 26_ QELMK 31_ QIDIM 36_ VAHKK 41_ SEWEG 46_ RTHAL 51_ ETCLK 56_ IREQE 61_ LKSLR 66_ SQLDV 71_ THKEV 76_ GMLHQ 81_ QVEEH 86_ EKIKQ 91_ EMTME 96_ YKQEL 101_ KKLHE 106_ ELCIL 111_ KRSYE 116_ KLQKK 121_ QMREF 126_ RGNTK 131_ NHRED 136_ RSEIE 141_ RLTAK 146_ IEEFR 151_ QKSLD 156_ WEKQR 161_ LIYQQ 166_ QVSSL 171_ EAQRK 176_ ALAEQ 181_ SEIIQ 186_ AQLVN 191_ RKQKL 196_ ESVEL 201_ SSQSE 206_ IQHLS 211_ SKLER 216_ ANDTI 221_ CANEL 226_ EIERL 231_ TMRVN 236_ DLVGT 241_ SMTVL 246_ QEQQQ 251_ KEEKL 256_ RESEK 261_ LLEAL 266_ QEEKR 271_ ELKAA 276_ LQSQE 281_ NLIHE 286_ ARIQK 291_ EKLQE 296_ KVKAT 301_ NTQHA 306_ VEAIR 311_ PREES 316_ LAEKK 321_ YTSQG 326_ QGDLD 331_ SVLSQ 336_ LNFTH 341_ TSEDL 346_ LQAEV 351_ TCLEG 356_ SLESV 361_ SATCK 366_ QLSQE 371_ LMEKY 376_ EELKR 381_ MEAHN 386_ NEYKA 391_ EIKKL 396_ KEQIL 401_ QGEQS 406_ YSSAL 411_ EGMKM 416_ EISHL 421_ TQELH 426_ QRDIT 431_ IASTK 436_ GSSSD 441_ MEKRL 446_ RAEMQ 451_ KAEDK 456_ AVEHK 461_ EILDQ 466_ LESLK 471_ LENRH 476_ LSEMV 481_ MKLEL 486_ GLHEA 491_ KEISL 496_ ADLQE 501_ NYIEA 506_ LNKLV 511_ SENQQ 516_ LQKDL 521_ MNTKS 526_ QLEIS 531_ TQMCK 536_ KQNDR 541_ IFKPT 546_ HSRTT 551_ EFKNT 556_ EFKPT 561_ HGQHR 566_ HDGIK 571_ TEHYK 576_ TDLHS 581_ PRGQA 586_ SDSIN 591_ PMSRV 596_ LSPLS 601_ PQISP 606_ CSSTR 611_ SLTSY 616_ SLCKT 621_ HSLPS 626_ ALDTN 631_ EANFS 636_ DTMSE 641_ SMNDQ 646_ EEFIS 651_ SCSLP 656_ VSPLG 661_ SIATR 666_ FLEEE 671_ ELRSH 676_ HILER 681_ LDAHI 686_ EELKR 691_ ESEKT 696_VRQFT
1: Required for normal spindle assembly (PubMed:21406398, PubMed:21983783, PubMed:26297806, PubMed:35793002). Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:21983783, PubMed:26297806). Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response (PubMed:21406398). Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398). Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination (PubMed:35989368)