Kremen protein 1 (Dickkopf receptor) (Kringle domain-containing transmembrane protein 1) (Kringle-containing protein marking the eye and the nose)
1_MAPPA 6_ ARLAL 11_ LSAAA 16_ LTLAA 21_ RPAPS 26_ PGLGP 31_ ECFTA 36_ NGADY 41_ RGTQN 46_ WTALQ 51_ GGKPC 56_ LFWNE 61_ TFQHP 66_ YNTLK 71_ YPNGE 76_ GGLGE 81_ HNYCR 86_ NPDGD 91_ VSPWC 96_ YVAEH 101_ EDGVY 106_ WKYCE 111_ IPACQ 116_ MPGNL 121_ GCYKD 126_ HGNPP 131_ PLTGT 136_ SKTSN 141_ KLTIQ 146_ TCISF 151_ CRSQR 156_ FKFAG 161_ MESGY 166_ ACFCG 171_ NNPDY 176_ WKYGE 181_ AASTE 186_ CNSVC 191_ FGDHT 196_ QPCGG 201_ DGRII 206_ LFDTL 211_ VGACG 216_ GNYSA 221_ MSSVV 226_ YSPDF 231_ PDTYA 236_ TGRVC 241_ YWTIR 246_ VPGAS 251_ HIHFS 256_ FPLFD 261_ IRDSA 266_ DMVEL 271_ LDGYT 276_ HRVLA 281_ RFHGR 286_ SRPPL 291_ SFNVS 296_ LDFVI 301_ LYFFS 306_ DRINQ 311_ AQGFA 316_ VLYQA 321_ VKEEL 326_ PQERP 331_ AVNQT 336_ VAEVI 341_ TEQAN 346_ LSVSA 351_ ARSSK 356_ VLYVI 361_ TTSPS 366_ HPPQT 371_ VPGSN 376_ SWAPP 381_ MGAGS 386_ HRVEG 391_ WTVYG 396_ LATLL 401_ ILTVT 406_ AIVAK 411_ ILLHV 416_ TFKSH 421_ RVPAS 426_ GDLRD 431_ CHQPG 436_ TSGEI 441_ WSIFY 446_ KPSTS 451_ ISIFK 456_ KKLKG 461_ QSQQD 466_DRNPL
1: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification