Palmitoyltransferase ZDHHC15 (EC 2.3.1.225) (Acyltransferase ZDHHC15) (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 15) (DHHC-15)
1_MRRGW 6_ KMALS 11_ GGLRC 16_ CRRVL 21_ SWVPV 26_ LVIVL 31_ VVLWS 36_ YYAYV 41_ FELCL 46_ VTVLS 51_ PAEKV 56_ IYLIL 61_ YHAIF 66_ VFFTW 71_ TYWKS 76_ IFTLP 81_ QQPNQ 86_ KFHLS 91_ YTDKE 96_ RYENE 101_ ERPEV 106_ QKQML 111_ VDMAK 116_ KLPVY 121_ TRTGS 126_ GAVRF 131_ CDRCH 136_ LIKPD 141_ RCHHC 146_ SVCAM 151_ CVLKM 156_ DHHCP 161_ WVNNC 166_ IGFSN 171_ YKFFL 176_ QFLAY 181_ SVLYC 186_ LYIAT 191_ TVFSY 196_ FIKYW 201_ RGELP 206_ SVRSK 211_ FHVLF 216_ LLFVA 221_ CMFFV 226_ SLVIL 231_ FGYHC 236_ WLVSR 241_ NKTTL 246_ EAFCT 251_ PVFTS 256_ GPEKN 261_ GFNLG 266_ FIKNI 271_ QQVFG 276_ DKKKF 281_ WLIPI 286_ GSSPG 291_ DGHSF 296_ PMRSM 301_ NESQN 306_ PLLAN 311_ EETWE 316_ DNEDD 321_ NQDYP 326_ EGSSS 331_LAVET
1: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:18817523, PubMed:23034182). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoylates IGF2R and SORT1, promoting their partitioning to an endosomal membrane subdomain where they can interact with the retromer cargo-selective complex (PubMed:18817523). Thereby, regulates retrograde transport from endosomes to the Golgi apparatus of these lysosomal sorting receptors and plays a role in trafficking of lysosomal proteins (PubMed:18817523). In the nervous system, catalyzes the palmitoylation of DLG4/PSD95 and regulates its synaptic clustering and function in synaptogenesis (By similarity). Could be involved in the differentiation of dopaminergic neurons and the development of the diencephalon (By similarity). Could also catalyze the palmitoylation of GAP43 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate FYN as shown in vitro (PubMed:19956733). May palmitoylate CALHM3 subunit of gustatory voltage-gated ion channels and modulate channel gating and kinetics