Integrator complex subunit 15
1_MSDIR 6_ HSLLR 11_ RDALS 16_ AAKEV 21_ LYHLD 26_ IYFSS 31_ QLQSA 36_ PLPIV 41_ DKGPV 46_ ELLEE 51_ FVFQV 56_ PKERS 61_ AQPKR 66_ LNSLQ 71_ ELQLL 76_ EIMCN 81_ YFQEQ 86_ TKDSV 91_ RQIIF 96_ SSLFS 101_ PQGNK 106_ ADDSR 111_ MSLLG 116_ KLVSM 121_ AVAVC 126_ RIPVL 131_ ECAAS 136_ WLQRT 141_ PVVYC 146_ VRLAK 151_ ALVDD 156_ YCCLV 161_ PGSIQ 166_ TLKQI 171_ FSASP 176_ RFCCQ 181_ FITSV 186_ TALYD 191_ LSSDD 196_ LIPPM 201_ DLLEM 206_ IVTWI 211_ FEDPR 216_ LILIT 221_ FLNTP 226_ IAANL 231_ PIGFL 236_ ELTPL 241_ VGLIR 246_ WCVKA 251_ PLAYK 256_ RKKKP 261_ PLSNG 266_ HVSNK 271_ VTKDP 276_ GVGMD 281_ RDSHL 286_ LYSKL 291_ HLSVL 296_ QVLMT 301_ LQLHL 306_ TEKNL 311_ YGRLG 316_ LILFD 321_ HMVPL 326_ VEEIN 331_ RLADE 336_ LNPLN 341_ ASQEI 346_ ELSLD 351_ RLAQA 356_ LQVAM 361_ ASGAL 366_ LCTRD 371_ DLRTL 376_ CSRLP 381_ HNNLL 386_ QLVIS 391_ GPVQQ 396_ SPHAA 401_ LPPGF 406_ YPHIH 411_ TPPLG 416_ YGAVP 421_ AHPAA 426_ HPALP 431_ THPGH 436_ TFISG 441_VTFPF
1: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:36920904, PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:38570683). INTS15 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386). Within the integrator complex, INTS15 is required to bridge different integrator modules (PubMed:36920904)