PWWP domain-containing protein 2A
1_MAAVA 6_ AEAAA 11_ TAASP 16_ GEGGA 21_ GEAEP 26_ EMEPI 31_ PGSEA 36_ GTDPL 41_ PVTAT 46_ EASVP 51_ DGETD 56_ GQQSA 61_ PQADE 66_ PPLPP 71_ PPPPP 76_ GELAR 81_ SPEAV 86_ GPELE 91_ AEEKL 96_ SVRVA 101_ ESAAA 106_ APQGG 111_ PELPP 116_ SPASP 121_ PEQPP 126_ APEER 131_ EEPPL 136_ PQPVA 141_ PALVP 146_ PAGGD 151_ STVSQ 156_ LIPGS 161_ EVRVT 166_ LDHII 171_ EDALV 176_ VSFRF 181_ GEKLF 186_ SGVLM 191_ DLSKR 196_ FGPHG 201_ IPVTV 206_ FPKRE 211_ YKDKP 216_ EAMPL 221_ QSNTF 226_ QEGTE 231_ VKCEA 236_ NGAVP 241_ DDPSP 246_ VPHPE 251_ LSLAE 256_ SLWTS 261_ KPPPL 266_ FHEGA 271_ PYPPP 276_ LFIRD 281_ TYNQS 286_ IPQPP 291_ PRKIK 296_ RPKRK 301_ MYREE 306_ PTSIM 311_ NAIKL 316_ RPRQV 321_ LCDKC 326_ KNSVV 331_ AEKKE 336_ IRKGS 341_ SATDS 346_ SKYED 351_ KKRRN 356_ ESVTT 361_ VNKKL 366_ KTDHK 371_ VDGKN 376_ QNESQ 381_ KRNAV 386_ VKVSN 391_ IAHSR 396_ GRVVK 401_ VSAQA 406_ NTSKA 411_ QLSTK 416_ KVLQS 421_ KNMDH 426_ AKARE 431_ VLKIA 436_ KEKAQ 441_ KKQNE 446_ TSTSK 451_ NAHSK 456_ VHFTR 461_ RYQNP 466_ SSGSL 471_ PPRVR 476_ LKPQR 481_ YRNEE 486_ NDSSL 491_ KTGLE 496_ KMRSG 501_ KMAPK 506_ PQSRC 511_ TSTRS 516_ AGEAP 521_ SENQS 526_ PSKGP 531_ EEASS 536_ EVQDT 541_ NEVHV 546_ PGDQD 551_ EPQTL 556_ GKKGS 561_ KNNIS 566_ VYMTL 571_ NQKKS 576_ DSSSA 581_ SVCSI 586_ DSTDD 591_ LKSSN 596_ SECSS 601_ SESFD 606_ FPPGS 611_ MHAPS 616_ TSSTS 621_ SSSKE 626_ EKKLS 631_ NSLKM 636_ KVFSK 641_ NVSKC 646_ VTPDG 651_ RTICV 656_ GDIVW 661_ AKIYG 666_ FPWWP 671_ ARILT 676_ ITVSR 681_ KDNGL 686_ LVRQE 691_ ARISW 696_ FGSPT 701_ TSFLA 706_ LSQLS 711_ PFLEN 716_ FQSRF 721_ NKKRK 726_ GLYRK 731_ AITEA 736_ AKAAK 741_ QLTPE 746_VRALL
1: Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:30327463). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260, PubMed:30327463). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (By similarity). Essential for proper mitosis progression (PubMed:28645917)