Dedicator of cytokinesis protein 7
1_MAERR 6_ AFAQK 11_ ISRTV 16_ AAEVR 21_ KQISG 26_ QYSGS 31_ PQLLK 36_ NLNIV 41_ GNISH 46_ HTTVP 51_ LTEAV 56_ DPVDL 61_ EDYLI 66_ THPLA 71_ VDSGP 76_ LRDLI 81_ EFPPD 86_ DIEVV 91_ YSPRD 96_ CRTLV 101_ SAVPE 106_ ESEMD 111_ PHVRD 116_ CIRSY 121_ TEDWA 126_ IVIRK 131_ YHKLG 136_ TGFNP 141_ NTLDK 146_ QKERQ 151_ KGLPK 156_ QVFES 161_ DEAPD 166_ GNSYQ 171_ DDQDD 176_ LKRRS 181_ MSIDD 186_ TPRGS 191_ WACSI 196_ FDLKN 201_ SLPDA 206_ LLPNL 211_ LDRTP 216_ NEEID 221_ RQNDD 226_ QRKSN 231_ RHKEL 236_ FALHP 241_ SPDEE 246_ EPIER 251_ LSVPD 256_ IPKEH 261_ FGQRL 266_ LVKCL 271_ SLKFE 276_ IEIEP 281_ IFASL 286_ ALYDV 291_ KEKKK 296_ ISENF 301_ YFDLN 306_ SEQMK 311_ GLLRP 316_ HVPPA 321_ AITTL 326_ ARSAI 331_ FSITY 336_ PSQDV 341_ FLVIK 346_ LEKVL 351_ QQGDI 356_ GECAE 361_ PYMIF 366_ KEADA 371_ TKNKE 376_ KLEKL 381_ KSQAD 386_ QFCQR 391_ LGKYR 396_ MPFAW 401_ TAIHL 406_ MNIVS 411_ SAGSL 416_ ERDST 421_ EVEIS 426_ TGERK 431_ GSWSE 436_ RRNSS 441_ IVGRR 446_ SLERT 451_ TSGDD 456_ ACNLT 461_ SFRPA 466_ TLTVT 471_ NFFKQ 476_ EGDRL 481_ SDEDL 486_ YKFLA 491_ DMRRP 496_ SSVLR 501_ RLRPI 506_ TAQLK 511_ IDISP 516_ APENP 521_ HYCLT 526_ PELLQ 531_ VKLYP 536_ DSRVR 541_ PTREI 546_ LEFPA 551_ RDVYV 556_ PNTTY 561_ RNLLY 566_ IYPQS 571_ LNFAN 576_ RQGSA 581_ RNITV 586_ KVQFM 591_ YGEDP 596_ SNAMP 601_ VIFGK 606_ SSCSE 611_ FSKEA 616_ YTAVV 621_ YHNRS 626_ PDFHE 631_ EIKVK 636_ LPATL 641_ TDHHH 646_ LLFTF 651_ YHVSC 656_ QQKQN 661_ TPLET 666_ PVGYT 671_ WIPML 676_ QNGRL 681_ KTGQF 686_ CLPVS 691_ LEKPP 696_ QAYSV 701_ LSPEV 706_ PLPGM 711_ KWVDN 716_ HKGVF 721_ NVEVV 726_ AVSSI 731_ HTQDP 736_ YLDKF 741_ FALVN 746_ ALDEH 751_ LFPVR 756_ IGDMR 761_ IMENN 766_ LENEL 771_ KSSIS 776_ ALNSS 781_ QLEPV 786_ VRFLH 791_ LLLDK 796_ LILLV 801_ IRPPV 806_ IAGQI 811_ VNLGQ 816_ ASFEA 821_ MASII 826_ NRLHK 831_ NLEGN 836_ HDQHG 841_ RNSLL 846_ ASYIH 851_ YVFRL 856_ PNTYP 861_ NSSSP 866_ GPGGL 871_ GGSVH 876_ YATMA 881_ RSAVR 886_ PASLN 891_ LNRSR 896_ SLSNS 901_ NPDIS 906_ GTPTS 911_ PDDEV 916_ RSIIG 921_ SKGLD 926_ RSNSW 931_ VNTGG 936_ PKAAP 941_ WGSNP 946_ SPSAE 951_ STQAM 956_ DRSCN 961_ RMSSH 966_ TETSS 971_ FLQTL 976_ TGRLP 981_ TKKLF 986_ HEELA 991_ LQWVV 996_ CSGSV 1001_ RESAL 1006_ QQAWF 1011_ FFELM 1016_ VKSMV 1021_ HHLYF 1026_ NDKLE 1031_ APRKS 1036_ RFPER 1041_ FMDDI 1046_ AALVS 1051_ TIASD 1056_ IVSRF 1061_ QKDTE 1066_ MVERL 1071_ NTSLA 1076_ FFLND 1081_ LLSVM 1086_ DRGFV 1091_ FSLIK 1096_ SCYKQ 1101_ VSSKL 1106_ YSLPN 1111_ PSVLV 1116_ SLRLD 1121_ FLRII 1126_ CSHEH 1131_ YVTLN 1136_ LPCSL 1141_ LTPPA 1146_ SPSPS 1151_ VSSAT 1156_ SQSSG 1161_ FSTNV 1166_ QDQKI 1171_ ANMFE 1176_ LSVPF 1181_ RQQHY 1186_ LAGLV 1191_ LTELA 1196_ VILDP 1201_ DAEGL 1206_ FGLHK 1211_ KVINM 1216_ VHNLL 1221_ SSHDS 1226_ DPRYS 1231_ DPQIK 1236_ ARVAM 1241_ LYLPL 1246_ IGIIM 1251_ ETVPQ 1256_ LYDFT 1261_ ETHNQ 1266_ RGRPI 1271_ CIATD 1276_ DYESE 1281_ SGSMI 1286_ SQTVA 1291_ MAIAG 1296_ TSVPQ 1301_ LTRPG 1306_ SFLLT 1311_ STSGR 1316_ QHTTF 1321_ SAESS 1326_ RSLLI 1331_ CLLWV 1336_ LKNAD 1341_ ETVLQ 1346_ KWFTD 1351_ LSVLQ 1356_ LNRLL 1361_ DLLYL 1366_ CVSCF 1371_ EYKGK 1376_ KVFER 1381_ MNSLT 1386_ FKKSK 1391_ DMRAK 1396_ LEEAI 1401_ LGSIG 1406_ ARQEM 1411_ VRRSR 1416_ GQLGT 1421_ YTIAS 1426_ PPERS 1431_ PSGSA 1436_ FGSQE 1441_ NLRWR 1446_ KDMTH 1451_ WRQNT 1456_ EKLDK 1461_ SRAEI 1466_ EHEAL 1471_ IDGNL 1476_ ATEAN 1481_ LIILD 1486_ TLEIV 1491_ VQTVS 1496_ VTESK 1501_ ESILG 1506_ GVLKV 1511_ LLHSM 1516_ ACNQS 1521_ AVYLQ 1526_ HCFAT 1531_ QRALV 1536_ SKFPE 1541_ LLFEE 1546_ ETEQC 1551_ ADLCL 1556_ RLLRH 1561_ CSSSI 1566_ GTIRS 1571_ HASAS 1576_ LYLLM 1581_ RQNFE 1586_ IGNNF 1591_ ARVKM 1596_ QVTMS 1601_ LSSLV 1606_ GTSQN 1611_ FNEEF 1616_ LRRSL 1621_ KTILT 1626_ YAEED 1631_ LELRE 1636_ TTFPD 1641_ QVQDL 1646_ VFNLH 1651_ MILSD 1656_ TVKMK 1661_ EHQED 1666_ PEMLI 1671_ DLMYR 1676_ IAKGY 1681_ QTSPD 1686_ LRLTW 1691_ LQNMA 1696_ GKHSE 1701_ RSNHA 1706_ EAAQC 1711_ LVHSA 1716_ ALVAE 1721_ YLSML 1726_ EDRKY 1731_ LPVGC 1736_ VTFQN 1741_ ISSNV 1746_ LEESA 1751_ VSDDV 1756_ VSPDE 1761_ EGICS 1766_ GKYFT 1771_ ESGLV 1776_ GLLEQ 1781_ AAASF 1786_ SMAGM 1791_ YEAVN 1796_ EVYKV 1801_ LIPIH 1806_ EANRD 1811_ AKKLS 1816_ TIHGK 1821_ LQEAF 1826_ SKIVH 1831_ QSTGW 1836_ ERMFG 1841_ TYFRV 1846_ GFYGT 1851_ KFGDL 1856_ DEQEF 1861_ VYKEP 1866_ AITKL 1871_ AEISH 1876_ RLEGF 1881_ YGERF 1886_ GEDVV 1891_ EVIKD 1896_ SNPVD 1901_ KCKLD 1906_ PNKAY 1911_ IQITY 1916_ VEPYF 1921_ DTYEM 1926_ KDRIT 1931_ YFDKN 1936_ YNLRR 1941_ FMYCT 1946_ PFTLD 1951_ GRAHG 1956_ ELHEQ 1961_ FKRKT 1966_ ILTTS 1971_ HAFPY 1976_ IKTRV 1981_ NVTHK 1986_ EEIIL 1991_ TPIEV 1996_ AIEDM 2001_ QKKTQ 2006_ ELAFA 2011_ THQDP 2016_ ADPKM 2021_ LQMVL 2026_ QGSVG 2031_ TTVNQ 2036_ GPLEV 2041_ AQVFL 2046_ SEIPS 2051_ DPKLF 2056_ RHHNK 2061_ LRLCF 2066_ KDFTK 2071_ RCEDA 2076_ LRKNK 2081_ SLIGP 2086_ DQKEY 2091_ QRELE 2096_ RNYHR 2101_ LKEAL 2106_ QPLIN 2111_ RKIPQ 2116_ LYKAV 2121_ LPVTC 2126_ HRDSF 2131_SRMSL
1: Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity)