Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2)
1_MTSAS 6_ PEDQN 11_ APVGC 16_ PKGAR 21_ RRRPI 26_ SVIGG 31_ VSLYG 36_ TNQTE 41_ ELDNL 46_ LTQPA 51_ SRPPM 56_ PAHQV 61_ PPYKA 66_ VSARF 71_ RPFTF 76_ SQSTP 81_ IGLDR 86_ VGRRR 91_ QMRAS 96_ NVSSD 101_ GGTEP 106_ SALVD 111_ DNGSE 116_ EDFSY 121_ EDLCQ 126_ ASPRY 131_ LQPGG 136_ EQLAI 141_ NELIS 146_ DGNVV 151_ CAEAL 156_ WDHVT 161_ MDDQE 166_ LGFKA 171_ GDVIQ 176_ VLEAS 181_ NKDWW 186_ WGRSE 191_ DKEAW 196_ FPASF 201_ VRLRV 206_ NQEEL 211_ SENSS 216_ STPSE 221_ EQDEE 226_ ASQSR 231_ HRHCE 236_ NKQQM 241_ RTNVI 246_ REIMD 251_ TERVY 256_ IKHLR 261_ DICEG 266_ YIRQC 271_ RKHTG 276_ MFTVA 281_ QLATI 286_ FGNIE 291_ DIYKF 296_ QRKFL 301_ KDLEK 306_ QYNKE 311_ EPHLS 316_ EIGSC 321_ FLQNQ 326_ EGFAI 331_ YSEYC 336_ NNHPG 341_ ACLEL 346_ ANLMK 351_ QGKYR 356_ HFFEA 361_ CRLLQ 366_ QMIDI 371_ AIDGF 376_ LLTPV 381_ QKICK 386_ YPLQL 391_ AELLK 396_ YTTQE 401_ HGDYS 406_ NIKAA 411_ YEAMK 416_ NVACL 421_ INERK 426_ RKLES 431_ IDKIA 436_ RWQVS 441_ IVGWE 446_ GLDIL 451_ DRSSE 456_ LIHSG 461_ ELTKI 466_ TKQGK 471_ SQQRT 476_ FFLFD 481_ HQLVS 486_ CKKDL 491_ LRRDM 496_ LYYKG 501_ RLDMD 506_ EMELV 511_ DLGDG 516_ RDKDC 521_ NLSVK 526_ NAFKL 531_ VSRTT 536_ DEVYL 541_ FCAKK 546_ QEDKA 551_ RWLQA 556_ CADER 561_ RRVQE 566_ DKEMG 571_ MEISE 576_ NQKKL 581_ AMLNA 586_ QKAGH 591_ GKSKG 596_ YNRCP 601_ VAPPH 606_ QGLHP 611_ IHQRH 616_ ITMPT 621_ SVPQQ 626_ QVFGL 631_ AEPKR 636_ KSSLF 641_ WHTFN 646_RLTPF
1: Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression