Retinol dehydrogenase 12 (EC 1.1.1.300) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2)
1_MLVTL 6_ GLLTS 11_ FFSFL 16_ YMVAP 21_ SIRKF 26_ FAGGV 31_ CRTNV 36_ QLPGK 41_ VVVIT 46_ GANTG 51_ IGKET 56_ ARELA 61_ SRGAR 66_ VYIAC 71_ RDVLK 76_ GESAA 81_ SEIRV 86_ DTKNS 91_ QVLVR 96_ KLDLS 101_ DTKSI 106_ RAFAE 111_ GFLAE 116_ EKQLH 121_ ILINN 126_ AGVMM 131_ CPYSK 136_ TADGF 141_ ETHLG 146_ VNHLG 151_ HFLLT 156_ YLLLE 161_ RLKVS 166_ APARV 171_ VNVSS 176_ VAHHI 181_ GKIPF 186_ HDLQS 191_ EKRYS 196_ RGFAY 201_ CHSKL 206_ ANVLF 211_ TRELA 216_ KRLQG 221_ TGVTT 226_ YAVHP 231_ GVVRS 236_ ELVRH 241_ SSLLC 246_ LLWRL 251_ FSPFV 256_ KTARE 261_ GAQTS 266_ LHCAL 271_ AEGLE 276_ PLSGK 281_ YFSDC 286_ KRTWV 291_ SPRAR 296_ NNKTA 301_ ERLWN 306_ VSCEL 311_LGIRW
1: Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol (PubMed:12226107, PubMed:15865448). Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal (PubMed:15865448, PubMed:19686838). May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:19686838). Has no dehydrogenase activity towards steroids (PubMed:12226107, PubMed:15865448)