Gene name: CCDC115

Uniprot entry:

Q96NT0

Protein names:

Coiled-coil domain-containing protein 115

Protein sequence:

1_MAALD 6_ LRAEL 11_ DSLVL 16_ QLLGD 21_ LEELE 26_ GKRTV 31_ LNARV 36_ EEGWL 41_ SLAKA 46_ RYAMG 51_ AKSVG 56_ PLQYA 61_ SHMEP 66_ QVCLH 71_ ASEAQ 76_ EGLQK 81_ FKVVR 86_ AGVHA 91_ PEEVG 96_ PREAG 101_ LRRRK 106_ GPTKT 111_ PEPES 116_ SEAPQ 121_ DPLNW 126_ FGILV 131_ PHSLR 136_ QAQAS 141_ FRDGL 146_ QLAAD 151_ IASLQ 156_ NRIDW 161_ GRSQL 166_ RGLQE 171_KLKQL

Protein annotations

Protein functions:

1: Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833332)