Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein)
1_MALYD 6_ EDLLK 11_ NPFYL 16_ ALQKC 21_ RPDLC 26_ SKVAQ 31_ IHGIV 36_ LVPCK 41_ GSLSS 46_ SIQST 51_ CQFES 56_ YILIP 61_ VEEHF 66_ QTLNG 71_ KDVFI 76_ QGNRI 81_ KLGAG 86_ FACLL 91_ SVPIL 96_ FEETF 101_ YNEKE 106_ ESFSI 111_ LCIAH 116_ PLEKR 121_ ESSEE 126_ PLAPS 131_ DPFSL 136_ KTIED 141_ VREFL 146_ GRHSE 151_ RFDRN 156_ IASFH 161_ RTFRE 166_ CERKS 171_ LRHHI 176_ DSANA 181_ LYTKC 186_ LQQLL 191_ RDSHL 196_ KMLAK 201_ QEAQM 206_ NLMKQ 211_ AVEIY 216_ VHHEI 221_ YNLIF 226_ KYVGT 231_ MEASE 236_ DAAFN 241_ KITRS 246_ LQDLQ 251_ QKDIG 256_ VKPEF 261_ SFNIP 266_ RAKRE 271_ LAQLN 276_ KCTSP 281_ QQKLV 286_ CLRKV 291_ VQLIT 296_ QSPSQ 301_ RVNLE 306_ TMCAD 311_ DLLSV 316_ LLYLL 321_ VKTEI 326_ PNWMA 331_ NLSYI 336_ KNFRF 341_ SSLAK 346_ DELGY 351_ CLTSF 356_ EAAIE 361_ YIRQG 366_ SLSAK 371_ PPESE 376_ GFGDR 381_ LFLKQ 386_ RMSLL 391_ SQMTS 396_ SPTDC 401_ LFKHI 406_ ASGNQ 411_ KEVER 416_ LLSQE 421_ DHDKD 426_ TVQKM 431_ CHPLC 436_ FCDDC 441_ EKLVS 446_ GRLND 451_ PSVVT 456_ PFSRD 461_ DRGHT 466_ PLHVA 471_ AVCGQ 476_ ASLID 481_ LLVSK 486_ GAMVN 491_ ATDYH 496_ GATPL 501_ HLACQ 506_ KGYQS 511_ VTLLL 516_ LHYKA 521_ SAEVQ 526_ DNNGN 531_ TPLHL 536_ ACTYG 541_ HEDCV 546_ KALVY 551_ YDVES 556_ CRLDI 561_ GNEKG 566_ DTPLH 571_ IAARW 576_ GYQGV 581_ IETLL 586_ QNGAS 591_ TEIQN 596_ RLKET 601_ PLKCA 606_ LNSKI 611_ LSVME 616_ AYHLS 621_ FERRQ 626_ KSSEA 631_ PVQSP 636_ QRSVD 641_ SISQE 646_ SSTSS 651_ FSSMS 656_ ASSRQ 661_ EETKK 666_ DYREV 671_ EKLLR 676_ AVADG 681_ DLEMV 686_ RYLLE 691_ WTEED 696_ LEDAE 701_ DTVSA 706_ ADPEF 711_ CHPLC 716_ QCPKC 721_ APAQK 726_ RLAKV 731_ PASGL 736_ GVNVT 741_ SQDGS 746_ SPLHV 751_ AALHG 756_ RADLI 761_ PLLLK 766_ HGANA 771_ GARNA 776_ DQAVP 781_ LHLAC 786_ QQGHF 791_ QVVKC 796_ LLDSN 801_ AKPNK 806_ KDLSG 811_ NTPLI 816_ YACSG 821_ GHHEL 826_ VALLL 831_ QHGAS 836_ INASN 841_ NKGNT 846_ ALHEA 851_ VIEKH 856_ VFVVE 861_ LLLLH 866_ GASVQ 871_ VLNKR 876_ QRTAV 881_ DCAEQ 886_ NSKIM 891_ ELLQV 896_ VPSCV 901_ ASLDD 906_ VAETD 911_ RKEYV 916_ TVKIR 921_ KKWNS 926_ KLYDL 931_ PDEPF 936_ TRQFY 941_ FVHSA 946_ GQFKG 951_ KTSRE 956_ IMARD 961_ RSVPN 966_ LTEGS 971_ LHEPG 976_ RQSVT 981_ LRQNN 986_ LPAQS 991_ GSHAA 996_ EKGNS 1001_ DWPER 1006_ PGLTQ 1011_ TGPGH 1016_ RRMLR 1021_ RHTVE 1026_ DAVVS 1031_ QGPEA 1036_ AGPLS 1041_TPQEV
1: May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (PubMed:24856514). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity)