Dachshund homolog 2 (Dach2)
1_MAVSA 6_ SPVIS 11_ ATSSG 16_ AGVPG 21_ GLFRA 26_ EPLYS 31_ TPREP 36_ PRLTP 41_ NMINS 46_ FVVNN 51_ HSNSA 56_ GGGGR 61_ GNTNT 66_ NECRM 71_ VDMHG 76_ MKVAS 81_ FLMDG 86_ QELIC 91_ LPQVF 96_ DLFLK 101_ HLVGG 106_ LHTVY 111_ TKLKR 116_ LDISP 121_ VVCTV 126_ EQVRI 131_ LRGLG 136_ AIQPG 141_ VNRCK 146_ LITRK 151_ DFETL 156_ FTDCT 161_ NARRK 166_ RQMTR 171_ KQAVN 176_ SSRPG 181_ RPPKR 186_ SLGVL 191_ QENAR 196_ LLTHA 201_ VPGLL 206_ SPGLI 211_ TPTGI 216_ TAAAM 221_ AEAMK 226_ LQKMK 231_ LMAMN 236_ TLQGN 241_ GSQNG 246_ TESEP 251_ DDLNS 256_ NTGGS 261_ ESSWD 266_ KDKMQ 271_ SPFAA 276_ PGPQH 281_ GIAHA 286_ ALAGQ 291_ PGIGG 296_ APTLN 301_ PLQQN 306_ HLLTN 311_ RLDLP 316_ FMMMP 321_ HPLLP 326_ VSLPP 331_ ASVAM 336_ AMNQM 341_ NHLNT 346_ IANMA 351_ AAAQI 356_ HSPLS 361_ RAGTS 366_ VIKER 371_ IPESP 376_ SPAPS 381_ LEENH 386_ RPGSQ 391_ TSSHT 396_ SSSVS 401_ SSPSQ 406_ MDHHL 411_ ERMEE 416_ VPVQI 421_ PIMKS 426_ PLDKI 431_ QLTPG 436_ QALPA 441_ GFPGP 446_ FIFAD 451_ SLSSV 456_ ETLLT 461_ NIQGL 466_ LKVAL 471_ DNARI 476_ QEKQI 481_ QQEKK 486_ ELRLE 491_ LYRER 496_ EIREN 501_ LERQL 506_ AVELQ 511_ SRTTM 516_ QKRLK 521_ KEKKT 526_ KRKLQ 531_ EALEF 536_ ESKRR 541_ EQVEQ 546_ ALKQA 551_ TTSDS 556_ GLRML 561_ KDTGI 566_ PDIEI 571_ ENNGT 576_ PHDSA 581_ AMQGG 586_ NYYCL 591_EMAQQ
1: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression also seems to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain