Chloride intracellular channel protein 6 (Parchorin)
1_MAEAA 6_ EPEGV 11_ APGPQ 16_ GPPEV 21_ PAPLA 26_ ERPGE 31_ PGAAG 36_ GEAEG 41_ PEGSE 46_ GAEEA 51_ PRGAA 56_ AVKEA 61_ GGGGP 66_ DRGPE 71_ AEARG 76_ TRGAH 81_ GETEA 86_ EEGAP 91_ EGAEV 96_ PQGGE 101_ ETSGA 106_ QQVEG 111_ ASPGR 116_ GAQGE 121_ PRGEA 126_ QREPE 131_ DSAAP 136_ ERQEE 141_ AEQRP 146_ EVPEG 151_ SASGE 156_ AGDSV 161_ DAEGP 166_ LGDNI 171_ EAEGP 176_ AGDSV 181_ EAEGR 186_ VGDSV 191_ DAEGP 196_ AGDSV 201_ DAEGP 206_ LGDNI 211_ QAEGP 216_ AGDSV 221_ DAEGR 226_ VGDSV 231_ DAEGP 236_ AGDSV 241_ DAEGR 246_ VGDSV 251_ EAGDP 256_ AGDGV 261_ EAGVP 266_ AGDSV 271_ EAEGP 276_ AGDSM 281_ DAEGP 286_ AGRAR 291_ RVSGE 296_ PQQSG 301_ DGSLS 306_ PQAEA 311_ IEVAA 316_ GESAG 321_ RSPGE 326_ LAWDA 331_ AEEAE 336_ VPGVK 341_ GSEEA 346_ APGDA 351_ RADAG 356_ EDRVG 361_ DGPQQ 366_ EPGED 371_ EERRE 376_ RSPEG 381_ PREEE 386_ AAGGE 391_ EESPD 396_ SSPHG 401_ EASRG 406_ AAEPE 411_ AQLSN 416_ HLAEE 421_ GPAEG 426_ SGEAA 431_ RVNGR 436_ REDGE 441_ ASEPR 446_ ALGQE 451_ HDITL 456_ FVKVK 461_ LTALG 466_ CSRIA 471_ IKKYL 476_ RAGYD 481_ GESIG 486_ NCPFS 491_ QRLFM 496_ ILWLK 501_ GVIFN 506_ VTTVD 511_ LKRKP 516_ ADLQN 521_ LAPGT 526_ NPPFM 531_ TFDGE 536_ VKTDV 541_ NKIEE 546_ FLEEK 551_ LAPPR 556_ YPKLG 561_ TQHPE 566_ SNSAG 571_ NDVFA 576_ KFSAF 581_ IKNTK 586_ KDANE 591_ IHEKN 596_ LLKAL 601_ RKLDN 606_ YLNSP 611_ LPDEI 616_ DAYST 621_ EDVTV 626_ SGRKF 631_ LDGDE 636_ LTLAD 641_ CNLLP 646_ KLHII 651_ KIVAK 656_ KYRDF 661_ EFPSE 666_ MTGIW 671_ RYLNN 676_ AYARD 681_ EFTNT 686_ CPADQ 691_ EIEHA 696_YSDVA
1: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages (PubMed:37838179). May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity)