Forkhead box protein N4
1_MIESD 6_ TSSIM 11_ SGIIR 16_ NSGQN 21_ HHPSP 26_ QEYRL 31_ LATTS 36_ DDDLP 41_ GDLQS 46_ LSWLT 51_ AVDVP 56_ RLQQM 61_ ASGRV 66_ DLGGP 71_ CVPHP 76_ HPGAL 81_ AGVAD 86_ LHVGA 91_ TPSPL 96_ LHGPA 101_ GMAPR 106_ GMPGL 111_ GPITG 116_ HRDSM 121_ SQFPV 126_ GGQPS 131_ SGLQD 136_ PPHLY 141_ SPATQ 146_ PQFPL 151_ PPGAQ 156_ QCPPV 161_ GLYGP 166_ PFGVR 171_ PPYPQ 176_ PHVAV 181_ HSSQE 186_ LHPKH 191_ YPKPI 196_ YSYSC 201_ LIAMA 206_ LKNSK 211_ TGSLP 216_ VSEIY 221_ SFMKE 226_ HFPYF 231_ KTAPD 236_ GWKNS 241_ VRHNL 246_ SLNKC 251_ FEKVE 256_ NKMSG 261_ SSRKG 266_ CLWAL 271_ NLARI 276_ DKMEE 281_ EMHKW 286_ KRKDL 291_ AAIHR 296_ SMANP 301_ EELDK 306_ LISDR 311_ PESCR 316_ RPGKP 321_ GEPEA 326_ PVLTH 331_ ATTVA 336_ VAHGC 341_ LAVSQ 346_ LPPQP 351_ LMTLS 356_ LQSVP 361_ LHHQV 366_ QPQAH 371_ LAPDS 376_ PAPAQ 381_ TPPLH 386_ ALPDL 391_ SPSPL 396_ PHPAM 401_ GRAPV 406_ DFINI 411_ STDMN 416_ TEVDA 421_ LDPSI 426_ MDFAL 431_ QGNLW 436_ EEMKD 441_ EGFSL 446_ DTLGA 451_ FADSP 456_ LGCDL 461_ GASGL 466_ TPASG 471_ GSDQS 476_ FPDLQ 481_ VTGLY 486_ TAYST 491_ PDSVA 496_ ASGTS 501_ SSSQY 506_ LGAQG 511_NKPIA
1: Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity)