Proline-rich acidic protein 1 (Epididymis tissue protein Li 178) (Uterine-specific proline-rich acidic protein)
1_MRRLL 6_ LVTSL 11_ VVVLL 16_ WEAGA 21_ VPAPK 26_ VPIKM 31_ QVKHW 36_ PSEQD 41_ PEKAW 46_ GARVV 51_ EPPEK 56_ DDQLV 61_ VLFPV 66_ QKPKL 71_ LTTEE 76_ KPRGQ 81_ GRGPI 86_ LPGTK 91_ AWMET 96_ EDTLG 101_ HVLSP 106_ EPDHD 111_ SLYHP 116_ PPEED 121_ QGEER 126_ PRLWV 131_ MPNHQ 136_ VLLGP 141_ EEDQD 146_HIYHP
1: Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (By similarity). Protects the gastrointestinal epithelium from irradiation-induced apoptosis (By similarity). May play an important role in maintaining normal growth homeostasis in epithelial cells (PubMed:14583459). Involved in p53/TP53-dependent cell survival after DNA damage (PubMed:23235459). May down-regulate the expression of MAD1L1 and exert a suppressive role in mitotic spindle assembly checkpoint in hepatocellular carcinomas (PubMed:24374861)