NACHT, LRR and PYD domains-containing protein 3 (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1)
1_MKMAS 6_ TRCKL 11_ ARYLE 16_ DLEDV 21_ DLKKF 26_ KMHLE 31_ DYPPQ 36_ KGCIP 41_ LPRGQ 46_ TEKAD 51_ HVDLA 56_ TLMID 61_ FNGEE 66_ KAWAM 71_ AVWIF 76_ AAINR 81_ RDLYE 86_ KAKRD 91_ EPKWG 96_ SDNAR 101_ VSNPT 106_ VICQE 111_ DSIEE 116_ EWMGL 121_ LEYLS 126_ RISIC 131_ KMKKD 136_ YRKKY 141_ RKYVR 146_ SRFQC 151_ IEDRN 156_ ARLGE 161_ SVSLN 166_ KRYTR 171_ LRLIK 176_ EHRSQ 181_ QEREQ 186_ ELLAI 191_ GKTKT 196_ CESPV 201_ SPIKM 206_ ELLFD 211_ PDDEH 216_ SEPVH 221_ TVVFQ 226_ GAAGI 231_ GKTIL 236_ ARKMM 241_ LDWAS 246_ GTLYQ 251_ DRFDY 256_ LFYIH 261_ CREVS 266_ LVTQR 271_ SLGDL 276_ IMSCC 281_ PDPNP 286_ PIHKI 291_ VRKPS 296_ RILFL 301_ MDGFD 306_ ELQGA 311_ FDEHI 316_ GPLCT 321_ DWQKA 326_ ERGDI 331_ LLSSL 336_ IRKKL 341_ LPEAS 346_ LLITT 351_ RPVAL 356_ EKLQH 361_ LLDHP 366_ RHVEI 371_ LGFSE 376_ AKRKE 381_ YFFKY 386_ FSDEA 391_ QARAA 396_ FSLIQ 401_ ENEVL 406_ FTMCF 411_ IPLVC 416_ WIVCT 421_ GLKQQ 426_ MESGK 431_ SLAQT 436_ SKTTT 441_ AVYVF 446_ FLSSL 451_ LQPRG 456_ GSQEH 461_ GLCAH 466_ LWGLC 471_ SLAAD 476_ GIWNQ 481_ KILFE 486_ ESDLR 491_ NHGLQ 496_ KADVS 501_ AFLRM 506_ NLFQK 511_ EVDCE 516_ KFYSF 521_ IHMTF 526_ QEFFA 531_ AMYYL 536_ LEEEK 541_ EGRTN 546_ VPGSR 551_ LKLPS 556_ RDVTV 561_ LLENY 566_ GKFEK 571_ GYLIF 576_ VVRFL 581_ FGLVN 586_ QERTS 591_ YLEKK 596_ LSCKI 601_ SQQIR 606_ LELLK 611_ WIEVK 616_ AKAKK 621_ LQIQP 626_ SQLEL 631_ FYCLY 636_ EMQEE 641_ DFVQR 646_ AMDYF 651_ PKIEI 656_ NLSTR 661_ MDHMV 666_ SSFCI 671_ ENCHR 676_ VESLS 681_ LGFLH 686_ NMPKE 691_ EEEEE 696_ KEGRH 701_ LDMVQ 706_ CVLPS 711_ SSHAA 716_ CSHGL 721_ VNSHL 726_ TSSFC 731_ RGLFS 736_ VLSTS 741_ QSLTE 746_ LDLSD 751_ NSLGD 756_ PGMRV 761_ LCETL 766_ QHPGC 771_ NIRRL 776_ WLGRC 781_ GLSHE 786_ CCFDI 791_ SLVLS 796_ SNQKL 801_ VELDL 806_ SDNAL 811_ GDFGI 816_ RLLCV 821_ GLKHL 826_ LCNLK 831_ KLWLV 836_ SCCLT 841_ SACCQ 846_ DLASV 851_ LSTSH 856_ SLTRL 861_ YVGEN 866_ ALGDS 871_ GVAIL 876_ CEKAK 881_ NPQCN 886_ LQKLG 891_ LVNSG 896_ LTSVC 901_ CSALS 906_ SVLST 911_ NQNLT 916_ HLYLR 921_ GNTLG 926_ DKGIK 931_ LLCEG 936_ LLHPD 941_ CKLQV 946_ LELDN 951_ CNLTS 956_ HCCWD 961_ LSTLL 966_ TSSQS 971_ LRKLS 976_ LGNND 981_ LGDLG 986_ VMMFC 991_ EVLKQ 996_ QSCLL 1001_ QNLGL 1006_ SEMYF 1011_ NYETK 1016_ SALET 1021_ LQEEK 1026_ PELTV 1031_VFEPS
1: Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:23582325, PubMed:25686105, PubMed:27929086, PubMed:28656979, PubMed:28847925, PubMed:30487600, PubMed:30612879, PubMed:31086327, PubMed:31086329, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:34512673, PubMed:36442502). In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC (PubMed:16407889, PubMed:18403674, PubMed:27432880, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:36142182, PubMed:36442502). Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis (PubMed:23582325, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353). Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses (PubMed:22801494). Under resting conditions, ADP-bound NLRP3 is autoinhibited (PubMed:35114687). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:19414800, PubMed:23871209). Almost all stimuli trigger intracellular K(+) efflux (By similarity). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex (PubMed:36442502, PubMed:39173637). Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) (PubMed:30487600, PubMed:34554188). Shows ATPase activity (PubMed:17483456)
2: Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (By similarity). Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (By similarity). May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity)