Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)
1_MAEAG 6_ DAALS 11_ VAEWL 16_ RALHL 21_ EQYTG 26_ LFEQH 31_ GLVWA 36_ TECQG 41_ LSDTR 46_ LMDMG 51_ MLLPG 56_ HRRRI 61_ LAGLL 66_ RAHTS 71_ PAPAP 76_ RPTPR 81_ PVPMK 86_ RHIFR 91_ SPPVP 96_ ATPPE 101_ PLPTT 106_ TEDEG 111_ LPAAP 116_ PIPPR 121_ RSCLP 126_ PTCFT 131_ TPSTA 136_ APDPV 141_ LPPLP 146_ AKRHL 151_ AELSV 156_ PPVPP 161_ RTGPP 166_ RLLVS 171_ LPTKE 176_ EESLL 181_ PSLSS 186_ PPQPQ 191_ SEEPL 196_ STLPQ 201_ GPPQP 206_ PSPPP 211_ CPPEI 216_ PPKPV 221_ RLFPE 226_ FDDSD 231_ YDEVP 236_ EEGPG 241_ APARV 246_ MTKKE 251_ EPPPS 256_ RVPRA 261_ VRVAS 266_ LLSEG 271_ EELSG 276_ DDQGD 281_ EEEDD 286_ HAYEG 291_ VPNGG 296_ WHTSS 301_ LSLSL 306_ PSTIA 311_ APHPM 316_ DGPPG 321_ GSTPV 326_ TPVIK 331_ AGWLD 336_ KNPPQ 341_ GSYIY 346_ QKRWV 351_ RLDTD 356_ HLRYF 361_ DSNKD 366_ AYSKR 371_ FISVA 376_ CISHV 381_ AAIGD 386_ QKFEV 391_ ITNNR 396_ TFAFR 401_ AESDV 406_ ERKEW 411_ MQALQ 416_ QAMAE 421_ QRARA 426_ RLSSA 431_ YLLGV 436_ PGSEQ 441_ PDRAG 446_ SLELR 451_ GFKNK 456_ LYVAV 461_ VGDKV 466_ QLYKN 471_ LEEYH 476_ LGIGI 481_ TFIDM 486_ SVGNV 491_ KEVDR 496_ RSFDL 501_ TTPYR 506_ IFSFS 511_ ADSEL 516_ EKEQW 521_ LEAMQ 526_ GAIAE 531_ ALSTS 536_ EVAER 541_ IWAAA 546_ PNRFC 551_ ADCGA 556_ PQPDW 561_ ASINL 566_ CVVIC 571_ KRCAG 576_ EHRGL 581_ GAGVS 586_ KVRSL 591_ KMDRK 596_ VWTET 601_ LIELF 606_ LQLGN 611_ GAGNR 616_ FWAAN 621_ VPPSE 626_ ALQPS 631_ SSPST 636_ RRCHL 641_ EAKYR 646_ EGKYR 651_ RYHPL 656_ FGNQE 661_ ELDKA 666_ LCAAV 671_ TTTDL 676_ AETQA 681_ LLGCG 686_ AGINC 691_ FSGDP 696_ EAPTP 701_ LALAE 706_ QAGQT 711_ LQMEF 716_ LRNNR 721_ TTEVP 726_ RLDSM 731_ KPLEK 736_ HYSVV 741_ LPTVS 746_ HSGFL 751_ YKTAS 756_ AGKLL 761_ QDRRA 766_ REEFS 771_ RRWCV 776_ LGDGV 781_ LSYFE 786_ NERAV 791_ TPNGE 796_ IRASE 801_ IVCLA 806_ VPPPD 811_ THGFE 816_ HTFEV 821_ YTEGE 826_ RLYLF 831_ GLESA 836_ EQAHE 841_ WVKCI 846_ AKAFV 851_ PPLAE 856_ DLLAR 861_ DFERL 866_ GRLPY 871_ KAGLS 876_ LQRAQ 881_ EGWFS 886_ LSGSE 891_ LRAVF 896_ PEGPC 901_ EEPLQ 906_ LRKLQ 911_ ELSIQ 916_ GDSEN 921_ QVLVL 926_ VERRR 931_ TLYIQ 936_ GERRL 941_ DFMGW 946_ LGAIQ 951_ KAAAS 956_ MGDTL 961_ SEQQL 966_ GDSDI 971_ PVIVY 976_ RCVDY 981_ ITQCG 986_ LTSEG 991_ IYRKC 996_ GQTSK 1001_ TQRLL 1006_ ESLRQ 1011_ DARSV 1016_ HLKEG 1021_ EQHVD 1026_ DVSSA 1031_ LKRFL 1036_ RDLPD 1041_ GLFTR 1046_ AQRLT 1051_ WLEAS 1056_ EIEDE 1061_ EEKVS 1066_ RYREL 1071_ LVRLP 1076_ PVNRA 1081_ TVKAL 1086_ ISHLY 1091_ CVQCF 1096_ SDTNQ 1101_ MNVHN 1106_ LAIVF 1111_ GPTLF 1116_ QTDGQ 1121_ DYKAG 1126_ RVVED 1131_ LINHY 1136_ VVVFS 1141_ VDEEE 1146_ LRKQR 1151_ EEITA 1156_ IVKMR 1161_ VAGTA 1166_ SGTQH 1171_ AGDFI 1176_ CTVYL 1181_ EEKKA 1186_ ETEQH 1191_ IKVPA 1196_ SMTAE 1201_ ELTLE 1206_ ILDRR 1211_ NVGIR 1216_ EKDYW 1221_ TCFEV 1226_ NEREE 1231_ AERPL 1236_ HFAEK 1241_ VLPIL 1246_ HGLGT 1251_ DSHLV 1256_ VKKHQ 1261_ AMEAM 1266_ LLYLA 1271_ SRVGD 1276_ TKHGM 1281_ MKFRE 1286_ DRSLL 1291_ GLGLP 1296_ SGGFH 1301_ DRYFI 1306_ LNSSC 1311_ LRLYK 1316_ EVRSQ 1321_ RPWSG 1326_ APETS 1331_ HRPEK 1336_ EWPIK 1341_ SLKVY 1346_ LGVKK 1351_ KLRPP 1356_ TCWGF 1361_ TVVHE 1366_ TEKHE 1371_ KQQWY 1376_ LCCDT 1381_ QMELR 1386_ EWFAT 1391_ FLFVQ 1396_ HDGLV 1401_ WPSEP 1406_ SRVSR 1411_ AVPEV 1416_ RLGSV 1421_ SLIPL 1426_ RGSEN 1431_ EMRRS 1436_ VAAFT 1441_ADPLS
1: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members (PubMed:11804590, PubMed:19666464). Activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and, to a lesser extent, by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) binding (PubMed:11804590). Has a preference for ARF1 and ARF5 (PubMed:11804590, PubMed:19666464). Positively regulates the ring size of circular dorsal ruffles and promotes macropinocytosis (PubMed:22573888). Acts as a bridging factor in osteoclasts to control actin and membrane dynamics (By similarity). Regulates the condensing of osteoclast podosomes into sealing zones which segregate the bone-facing membrane from other membrane domains and are required for osteoclast resorption activity (By similarity). Also regulates recruitment of the AP-3 complex to endosomal membranes and trafficking of lysosomal membrane proteins to the ruffled membrane border of osteoclasts to modulate bone resorption (By similarity). Regulates the endocytic trafficking of EGFR (PubMed:18764928, PubMed:18939958, PubMed:21275903). Regulates the incorporation of CD63 and CD9 into multivesicular bodies (PubMed:38682696). Required in the retinal pigment epithelium (RPE) for photoreceptor survival due to its role in promoting RPE phagocytosis (By similarity)