WD repeat and FYVE domain-containing protein 2 (Propeller-FYVE protein) (Prof) (WD40- and FYVE domain-containing protein 2) (Zinc finger FYVE domain-containing protein 22)
1_MAAEI 6_ QPKPL 11_ TRKPI 16_ LLQRM 21_ EGSQE 26_ VVNMA 31_ VIVPK 36_ EEGVI 41_ SVSED 46_ RTVRV 51_ WLKRD 56_ SGQYW 61_ PSVYH 66_ AMPSP 71_ CSCMS 76_ FNPET 81_ RRLSI 86_ GLDNG 91_ TISEF 96_ ILSED 101_ YNKMT 106_ PVKNY 111_ QAHQS 116_ RVTMI 121_ LFVLE 126_ LEWVL 131_ STGQD 136_ KQFAW 141_ HCSES 146_ GQRLG 151_ GYRTS 156_ AVASG 161_ LQFDV 166_ ETRHV 171_ FIGDH 176_ SGQVT 181_ ILKLE 186_ QENCT 191_ LVTTF 196_ RGHTG 201_ GVTAL 206_ CWDPV 211_ QRVLF 216_ SGSSD 221_ HSVIM 226_ WDIGG 231_ RKGTA 236_ IELQG 241_ HNDRV 246_ QALSY 251_ AQHTR 256_ QLISC 261_ GGDGG 266_ IVVWN 271_ MDVER 276_ QETPE 281_ WLDSD 286_ SCQKC 291_ DQPFF 296_ WNFKQ 301_ MWDSK 306_ KIGLR 311_ QHHCR 316_ KCGKA 321_ VCGKC 326_ SSKRS 331_ SIPLM 336_ GFEFE 341_ VRVCD 346_ SCHEA 351_ ITDEE 356_ RAPTA 361_ TFHDS 366_ KHNIV 371_ HVHFD 376_ ATRGW 381_ LLTSG 386_ TDKVI 391_KLWDM
1: Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553)