2-oxoglutarate receptor 1 (Alpha-ketoglutarate receptor 1) (G-protein coupled receptor 80) (G-protein coupled receptor 99) (P2Y purinoceptor 15) (P2Y15) (P2Y-like GPCR) (P2Y-like nucleotide receptor)
1_MNEPL 6_ DYLAN 11_ ASDFP 16_ DYAAA 21_ FGNCT 26_ DENIP 31_ LKMHY 36_ LPVIY 41_ GIIFL 46_ VGFPG 51_ NAVVI 56_ STYIF 61_ KMRPW 66_ KSSTI 71_ IMLNL 76_ ACTDL 81_ LYLTS 86_ LPFLI 91_ HYYAS 96_ GENWI 101_ FGDFM 106_ CKFIR 111_ FSFHF 116_ NLYSS 121_ ILFLT 126_ CFSIF 131_ RYCVI 136_ IHPMS 141_ CFSIH 146_ KTRCA 151_ VVACA 156_ VVWII 161_ SLVAV 166_ IPMTF 171_ LITST 176_ NRTNR 181_ SACLD 186_ LTSSD 191_ ELNTI 196_ KWYNL 201_ ILTAT 206_ TFCLP 211_ LVIVT 216_ LCYTT 221_ IIHTL 226_ THGLQ 231_ TDSCL 236_ KQKAR 241_ RLTIL 246_ LLLAF 251_ YVCFL 256_ PFHIL 261_ RVIRI 266_ ESRLL 271_ SISCS 276_ IENQI 281_ HEAYI 286_ VSRPL 291_ AALNT 296_ FGNLL 301_ LYVVV 306_ SDNFQ 311_ QAVCS 316_ TVRCK 321_ VSGNL 326_ EQAKK 331_ISYSN
1: G protein-coupled receptor for dicarboxylates and amino dicarboxylates (PubMed:15141213, PubMed:36571463, PubMed:36919698). Receptor for itaconate, a metabolite produced by myeloid lineages (PubMed:36919698). In the respiratory epithelium, couples the binding of itaconate to the activation of GNA11 and downstream intracellular Ca(2+) release, leading to mucocilliary clearance of airborne pathogens (PubMed:36919698). Receptor for leukotriene E4 (LTE4) produced by mast cells upon allergic inflammation. Binds with high affinity to LTE4 and elicits mucin release from pulmonary epithelium in response to airborne fungi allergens. Regulates mucin-producing goblet cell homeostasis (By similarity). Receptor for alpha-ketoglutarate produced by proximal tubule renal cells upon metabolic alkalosis. In an intrarenal paracrine signaling pathway, binds alpha-ketoglutarate and drives transepithelial salt reabsorption and bicarbonate secretion by SLC26A4/pendrin-positive intercalated cells (By similarity) (PubMed:15141213)