Importin-9 (Imp9) (Ran-binding protein 9) (RanBP9)
1_MAAAA 6_ AAGAA 11_ SGLPG 16_ PVAQG 21_ LKEAL 26_ VDTLT 31_ GILSP 36_ VQEVR 41_ AAAEE 46_ QIKVL 51_ EVTEE 56_ FGVHL 61_ AELTV 66_ DPQGA 71_ LAIRQ 76_ LASVI 81_ LKQYV 86_ ETHWC 91_ AQSEK 96_ FRPPE 101_ TTERA 106_ KIVIR 111_ ELLPN 116_ GLRES 121_ ISKVR 126_ SSVAY 131_ AVSAI 136_ AHWDW 141_ PEAWP 146_ QLFNL 151_ LMEML 156_ VSGDL 161_ NAVHG 166_ AMRVL 171_ TEFTR 176_ EVTDT 181_ QMPLV 186_ APVIL 191_ PEMYK 196_ IFTMA 201_ EVYGI 206_ RTRSR 211_ AVEIF 216_ TTCAH 221_ MICNM 226_ EELEK 231_ GAAKV 236_ LIFPV 241_ VQQFT 246_ EAFVQ 251_ ALQIP 256_ DGPTS 261_ DSGFK 266_ MEVLK 271_ AVTAL 276_ VKNFP 281_ KHMVS 286_ SMQQI 291_ LPIVW 296_ NTLTE 301_ SAAFY 306_ VRTEV 311_ NYTEE 316_ VEDPV 321_ DSDGE 326_ VLGFE 331_ NLVFS 336_ IFEFV 341_ HALLE 346_ NSKFK 351_ STVKK 356_ ALPEL 361_ IYYII 366_ LYMQI 371_ TEEQI 376_ KVWTA 381_ NPQQF 386_ VEDED 391_ DDTFS 396_ YTVRI 401_ AAQDL 406_ LLAVA 411_ TDFQN 416_ ESAAA 421_ LAAAA 426_ TRHLQ 431_ EAEQT 436_ KNSGT 441_ EHWWK 446_ IHEAC 451_ MLALG 456_ SVKAI 461_ ITDSV 466_ KNGRI 471_ HFDMH 476_ GFLTN 481_ VILAD 486_ LNLSV 491_ SPFLL 496_ GRALW 501_ AASRF 506_ TVAMS 511_ PELIQ 516_ QFLQA 521_ TVSGL 526_ HETQP 531_ PSVRI 536_ SAVRA 541_ IWGYC 546_ DQLKV 551_ SESTH 556_ VLQPF 561_ LPSIL 566_ DGLIH 571_ LAAQF 576_ SSEVL 581_ NLVME 586_ TLCIV 591_ CTVDP 596_ EFTAS 601_ MESKI 606_ CPFTI 611_ AIFLK 616_ YSNDP 621_ VVASL 626_ AQDIF 631_ KELSQ 636_ IEACQ 641_ GPMQM 646_ RLIPT 651_ LVSIM 656_ QAPAD 661_ KIPAG 666_ LCATA 671_ IDILT 676_ TVVRN 681_ TKPPL 686_ SQLLI 691_ CQAFP 696_ AVAQC 701_ TLHTD 706_ DNATM 711_ QNGGE 716_ CLRAY 721_ VSVTL 726_ EQVAQ 731_ WHDEQ 736_ GHNGL 741_ WYVMQ 746_ VVSQL 751_ LDPRT 756_ SEFTA 761_ AFVGR 766_ LVSTL 771_ ISKAG 776_ RELGE 781_ NLDQI 786_ LRAIL 791_ SKMQQ 796_ AETLS 801_ VMQSL 806_ IMVFA 811_ HLVHT 816_ QLEPL 821_ LEFLC 826_ SLPGP 831_ TGKPA 836_ LEFVM 841_ AEWTS 846_ RQHLF 851_ YGQYE 856_ GKVSS 861_ VALCK 866_ LLQHG 871_ INADD 876_ KRLQD 881_ IRVKG 886_ EEIYS 891_ MDEGI 896_ RTRSK 901_ SAKNP 906_ ERWTN 911_ IPLLV 916_ KILKL 921_ IINEL 926_ SNVME 931_ ANAAR 936_ QATPA 941_ EWSQD 946_ DSNDM 951_ WEDQE 956_ EEEEE 961_ EEDGL 966_ AGQLL 971_ SDILA 976_ TSKYE 981_ EDYYE 986_ DDEED 991_ DPDAL 996_ KDPLY 1001_ QIDLQ 1006_ AYLTD 1011_ FLCQF 1016_ AQQPC 1021_ YIMFS 1026_ GHLND 1031_ NERRV 1036_LQTIG
1: Nuclear transport receptor that mediates nuclear import of proteins, such as histones, proteasome and actin (PubMed:11823430, PubMed:30855230, PubMed:34711951). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the import of pre-assembled proteasomes into the nucleus; AKIRIN2 acts as a molecular bridge between IPO9 and the proteasome complex (PubMed:11823430, PubMed:34711951). Mediates the nuclear import of histones H2A, H2B, H4 and H4 (PubMed:11823430, PubMed:30855230). In addition to nuclear import, also acts as a chaperone for histones by preventing inappropriate non-nucleosomal interactions (PubMed:30855230). Mediates the nuclear import of actin (By similarity)