2-acylglycerol O-acyltransferase 1 (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 1) (MGAT1) (Diacylglycerol O-acyltransferase candidate 2) (hDC2) (Diacylglycerol acyltransferase 2-like protein 1) (Monoacylglycerol O-acyltransferase 1)
1_MKVEF 6_ APLNI 11_ QLARR 16_ LQTVA 21_ VLQWV 26_ LKYLL 31_ LGPMS 36_ IGITV 41_ MLIIH 46_ NYLFL 51_ YIPYL 56_ MWLYF 61_ DWHTP 66_ ERGGR 71_ RSSWI 76_ KNWTL 81_ WKHFK 86_ DYFPI 91_ HLIKT 96_ QDLDP 101_ SHNYI 106_ FGFHP 111_ HGIMA 116_ VGAFG 121_ NFSVN 126_ YSDFK 131_ DLFPG 136_ FTSYL 141_ HVLPL 146_ WFWCP 151_ VFREY 156_ VMSVG 161_ LVSVS 166_ KKSVS 171_ YMVSK 176_ EGGGN 181_ ISVIV 186_ LGGAK 191_ ESLDA 196_ HPGKF 201_ TLFIR 206_ QRKGF 211_ VKIAL 216_ THGAS 221_ LVPVV 226_ SFGEN 231_ ELFKQ 236_ TDNPE 241_ GSWIR 246_ TVQNK 251_ LQKIM 256_ GFALP 261_ LFHAR 266_ GVFQY 271_ NFGLM 276_ TYRKA 281_ IHTVV 286_ GRPIP 291_ VRQTL 296_ NPTQE 301_ QIEEL 306_ HQTYM 311_ EELRK 316_ LFEEH 321_ KGKYG 326_IPEHE
1: Involved in glycerolipid synthesis and lipid metabolism. Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol, mainly at the sn-1 or sn-3 positions. It uses both sn-2-monoacylglycerol (2-acylglycerol) and sn-1-monoacylglycerol (1-acyl-sn-glycerol) equally well as substrates, and uses sn-3-monoacylglycerol (3-acyl-sn-glycerol) with lower efficiency. Probably not involved in absorption of dietary fat in the small intestine