Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase 2)
1_MKTLI 6_ AAYSG 11_ VLRGE 16_ RQAEA 21_ DRSQR 26_ SHGGP 31_ ALSRE 36_ GSGRW 41_ GTGSS 46_ ILSAL 51_ QDLFS 56_ VTWLN 61_ RSKVE 66_ KQLQV 71_ ISVLQ 76_ WVLSF 81_ LVLGV 86_ ACSAI 91_ LMYIF 96_ CTDCW 101_ LIAVL 106_ YFTWL 111_ VFDWN 116_ TPKKG 121_ GRRSQ 126_ WVRNW 131_ AVWRY 136_ FRDYF 141_ PIQLV 146_ KTHNL 151_ LTTRN 156_ YIFGY 161_ HPHGI 166_ MGLGA 171_ FCNFS 176_ TEATE 181_ VSKKF 186_ PGIRP 191_ YLATL 196_ AGNFR 201_ MPVLR 206_ EYLMS 211_ GGICP 216_ VSRDT 221_ IDYLL 226_ SKNGS 231_ GNAII 236_ IVVGG 241_ AAESL 246_ SSMPG 251_ KNAVT 256_ LRNRK 261_ GFVKL 266_ ALRHG 271_ ADLVP 276_ IYSFG 281_ ENEVY 286_ KQVIF 291_ EEGSW 296_ GRWVQ 301_ KKFQK 306_ YIGFA 311_ PCIFH 316_ GRGLF 321_ SSDTW 326_ GLVPY 331_ SKPIT 336_ TVVGE 341_ PITIP 346_ KLEHP 351_ TQQDI 356_ DLYHT 361_ MYMEA 366_ LVKLF 371_ DKHKT 376_ KFGLP 381_ETEVL
1: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (PubMed:27184406). Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Also functions as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705)