Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5)
1_MGAGG 6_ RRMRG 11_ APARL 16_ LLPLL 21_ PWLLL 26_ LLAPE 31_ ARGAP 36_ GCPLS 41_ IRSCK 46_ CSGER 51_ PKGLS 56_ GGVPG 61_ PARRR 66_ VVCSG 71_ GDLPE 76_ PPEPG 81_ LLPNG 86_ TVTLL 91_ LSNNK 96_ ITGLR 101_ NGSFL 106_ GLSLL 111_ EKLDL 116_ RNNII 121_ STVQP 126_ GAFLG 131_ LGELK 136_ RLDLS 141_ NNRIG 146_ CLTSE 151_ TFQGL 156_ PRLLR 161_ LNISG 166_ NIFSS 171_ LQPGV 176_ FDELP 181_ ALKVV 186_ DLGTE 191_ FLTCD 196_ CHLRW 201_ LLPWA 206_ QNRSL 211_ QLSEH 216_ TLCAY 221_ PSALH 226_ AQALG 231_ SLQEA 236_ QLCCE 241_ GALEL 246_ HTHHL 251_ IPSLR 256_ QVVFQ 261_ GDRLP 266_ FQCSA 271_ SYLGN 276_ DTRIR 281_ WYHNR 286_ APVEG 291_ DEQAG 296_ ILLAE 301_ SLIHD 306_ CTFIT 311_ SELTL 316_ SHIGV 321_ WASGE 326_ WECTV 331_ SMAQG 336_ NASKK 341_ VEIVV 346_ LETSA 351_ SYCPA 356_ ERVAN 361_ NRGDF 366_ RWPRT 371_ LAGIT 376_ AYQSC 381_ LQYPF 386_ TSVPL 391_ GGGAP 396_ GTRAS 401_ RRCDR 406_ AGRWE 411_ PGDYS 416_ HCLYT 421_ NDITR 426_ VLYTF 431_ VLMPI 436_ NASNA 441_ LTLAH 446_ QLRVY 451_ TAEAA 456_ SFSDM 461_ MDVVY 466_ VAQMI 471_ QKFLG 476_ YVDQI 481_ KELVE 486_ VMVDM 491_ ASNLM 496_ LVDEH 501_ LLWLA 506_ QREDK 511_ ACSRI 516_ VGALE 521_ RIGGA 526_ ALSPH 531_ AQHIS 536_ VNARN 541_ VALEA 546_ YLIKP 551_ HSYVG 556_ LTCTA 561_ FQRRE 566_ GGVPG 571_ TRPGS 576_ PGQNP 581_ PPEPE 586_ PPADQ 591_ QLRFR 596_ CTTGR 601_ PNVSL 606_ SSFHI 611_ KNSVA 616_ LASIQ 621_ LPPSL 626_ FSSLP 631_ AALAP 636_ PVPPD 641_ CTLQL 646_ LVFRN 651_ GRLFH 656_ SHSNT 661_ SRPGA 666_ AGPGK 671_ RRGVA 676_ TPVIF 681_ AGTSG 686_ CGVGN 691_ LTEPV 696_ AVSLR 701_ HWAEG 706_ AEPVA 711_ AWWSQ 716_ EGPGE 721_ AGGWT 726_ SEGCQ 731_ LRSSQ 736_ PNVSA 741_ LHCQH 746_ LGNVA 751_ VLMEL 756_ SAFPR 761_ EVGGA 766_ GAGLH 771_ PVVYP 776_ CTALL 781_ LLCLF 786_ ATIIT 791_ YILNH 796_ SSIRV 801_ SRKGW 806_ HMLLN 811_ LCFHI 816_ AMTSA 821_ VFAGG 826_ ITLTN 831_ YQMVC 836_ QAVGI 841_ TLHYS 846_ SLSTL 851_ LWMGV 856_ KARVL 861_ HKELT 866_ WRAPP 871_ PQEGD 876_ PALPT 881_ PSPML 886_ RFYLI 891_ AGGIP 896_ LIICG 901_ ITAAV 906_ NIHNY 911_ RDHSP 916_ YCWLV 921_ WRPSL 926_ GAFYI 931_ PVALI 936_ LLITW 941_ IYFLC 946_ AGLRL 951_ RGPLA 956_ QNPKA 961_ GNSRA 966_ SLEAG 971_ EELRG 976_ STRLR 981_ GSGPL 986_ LSDSG 991_ SLLAT 996_ GSARV 1001_ GTPGP 1006_ PEDGD 1011_ SLYSP 1016_ GVQLG 1021_ ALVTT 1026_ HFLYL 1031_ AMWAC 1036_ GALAV 1041_ SQRWL 1046_ PRVVC 1051_ SCLYG 1056_ VAASA 1061_ LGLFV 1066_ FTHHC 1071_ ARRRD 1076_ VRASW 1081_ RACCP 1086_ PASPA 1091_ APHAP 1096_ PRALP 1101_ AAAED 1106_ GSPVF 1111_ GEGPP 1116_ SLKSS 1121_ PSGSS 1126_ GHPLA 1131_ LGPCK 1136_ LTNLQ 1141_ LAQSQ 1146_ VCEAG 1151_ AAAGG 1156_ EGEPE 1161_ PAGTR 1166_ GNLAH 1171_ RHPNN 1176_ VHHGR 1181_ RAHKS 1186_ RAKGH 1191_ RAGEA 1196_ CGKNR 1201_ LKALR 1206_ GGAAG 1211_ ALELL 1216_ SSESG 1221_ SLHNS 1226_ PTDSY 1231_ LGSSR 1236_ NSPGA 1241_ GLQLE 1246_ GEPML 1251_ TPSEG 1256_ SDTSA 1261_ APLSE 1266_ AGRAG 1271_ QRRSA 1276_ SRDSL 1281_ KGGGA 1286_ LEKES 1291_ HRRSY 1296_ PLNAA 1301_ SLNGA 1306_ PKGGK 1311_ YDDVT 1316_ LMGAE 1321_ VASGG 1326_ CMKTG 1331_LWKSE
1: Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628)