Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66)
1_MTARE 6_ HSPRH 11_ GARAR 16_ AMQRA 21_ STIDV 26_ AADML 31_ GLSLA 36_ GNIQD 41_ PDEPI 46_ LEFSL 51_ ACSEL 56_ HTPSL 61_ DRKPN 66_ SFVAV 71_ SVTTP 76_ PQAFW 81_ TKHAQ 86_ TEIIE 91_ GTNNP 96_ IFLSS 101_ IAFFQ 106_ DSLIN 111_ QMTQV 116_ KLSVY 121_ DVKDR 126_ SQGTM 131_ YLLGS 136_ GTFIV 141_ KDLLQ 146_ DRHHR 151_ LHLTL 156_ RSAES 161_ DRVGN 166_ ITVIG 171_ WQMEE 176_ KSDQR 181_ PPVTR 186_ SVDTV 191_ NGRMV 196_ LPVDE 201_ SLTEA 206_ LGIRS 211_ KYASL 216_ RKDTL 221_ LKSVF 226_ GGAIC 231_ RMYRF 236_ PTTDG 241_ NHLRI 246_ LEQMA 251_ ESVLS 256_ LHVPR 261_ QFVKL 266_ LLEED 271_ AARVC 276_ ELEEL 281_ GELSP 286_ CWESL 291_ RRQIV 296_ TQYQT 301_ IILTY 306_ QENLT 311_ DLHQY 316_ RGPSF 321_ KASSL 326_ KADKK 331_ LEFVP 336_ TNLHI 341_ QRMRV 346_ QDDGG 351_ SDQNY 356_ DIVTI 361_ GAPAA 366_ HCQGF 371_ KSGGL 376_ RKKLH 381_ KFEET 386_ KKHFE 391_ ECCTS 396_ SGCQS 401_ IIYIP 406_ QDVVR 411_ AKEII 416_ AQINT 421_ LKTQV 426_ SYYAE 431_ RLSRA 436_ AKDRS 441_ ATGLE 446_ RTLAI 451_ LADKT 456_ RQLVT 461_ VCDCK 466_ LLANS 471_ IHGLN 476_ AARPD 481_ YIASK 486_ ASPTS 491_ TEEEQ 496_ VMLRN 501_ DQDTL 506_ MARWT 511_ GRNSR 516_ SSLQV 521_ DWHEE 526_ EWEKV 531_ WLNVD 536_ KSLEC 541_ IIQRV 546_ DKLLQ 551_ KERLH 556_ GEGCE 561_ DVFPC 566_ AGSCT 571_ SKKGN 576_ PDSHA 581_ YWIRP 586_ EDPFC 591_ DVPSS 596_ PCPST 601_ MPSTA 606_ CHPHL 611_ TTHCS 616_ PPPEE 621_ SSPGE 626_ WSEAL 631_ YPLLT 636_ TLTDC 641_ VAMMS 646_ DKAKK 651_ AMVFL 656_ LMQDS 661_ APTIA 666_ TYLSL 671_ QYRRD 676_ VVFCQ 681_ TLTAL 686_ ICGFI 691_ IKLRN 696_ CLHDD 701_ GFLRQ 706_ LYTIG 711_ LLAQF 716_ ESLLS 721_ TYGEE 726_ LAMLE 731_ DMSLG 736_ IMDLR 741_ NVTFK 746_ VTQAT 751_ SSASA 756_ DMLPV 761_ ITGNR 766_ DGFNV 771_ RVPLP 776_ GPLFD 781_ ALPRE 786_ IQSGM 791_ LLRVQ 796_ PVLFN 801_ VGINE 806_ QQTLA 811_ ERFGD 816_ TSLQE 821_ VINVE 826_ SLVRL 831_ NSYFE 836_ QFKEV 841_ LPEDC 846_ LPRSR 851_ SQTCL 856_ PELLR 861_ FLGQN 866_ VHARK 871_ NKNVD 876_ ILWQA 881_ AEICR 886_ RLNGV 891_ RFTSC 896_ KSAKD 901_ RTAMS 906_ VTLEQ 911_ CLILQ 916_ HEHGM 921_ APQVF 926_ TQALE 931_ CMRSE 936_ GCRRE 941_ NTMKN 946_ VGSRK 951_ YAFNS 956_ LQLKA 961_ FPKHY 966_ RPPEG 971_TYGKV
1: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15716355, PubMed:20463662). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity) (PubMed:30071275). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity)
2: Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3